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The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Cancer Cell Int. 2021-11; 
Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang
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Proteins, Expression, Isolation and Analysis equal amounts of denatured proteins (20ug) were separated on 4–12% NuPAGE Bis-Tris Gel (Cat# No. M00653; GenScript, Piscataway, NJ, USA) Get A Quote


background: Circular RNAs (circRNAs), which are endogenous non-coding RNAs, are associated with various biological processes including development, homeostatic maintenance, and pathological responses. Accumulating evidence has implicated non-coding RNAs in cancer progression, and the role of circRNAs in particular has drawn wide attention. However, circRNA expression patterns and functions in hepatocellular carcinoma (HCC) remain poorly understood. methods: CircRNA sequencing was performed to screen differentially expressed circRNAs in HCC. Northern blotting, quantitative real-time polymerase chain reaction, nucleocytoplasmic fractionation, and fluorescence in situ hybridization analyses were conducted to evalu... More


CDK1, Cell cycle, Competing endogenous RNA, Hepatocellular carcinogenesis, circRNA