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Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics

Nat Nanotechnol. 2022-12; 
Changrong Shi , Qianyu Zhang , Yuying Yao , Fantian Zeng , Chao Du , Sureya Nijiati , Xuejun Wen , Xinyi Zhang , Hongzhang Yang , Haoting Chen , Zhide Guo , Xianzhong Zhang , Jinhao Gao , Weisheng Guo , Xiaoyuan Chen , Zijian Zhou
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T cells play a determining role in the immunomodulation and prognostic evaluation of cancer treatments relying on immune activation. While specific biomarkers determine the population and distribution of T cells in tumours, the in situ activity of T cells is less studied. Here we designed T-cell-targeting fusogenic liposomes to regulate and quantify the activity of T cells by exploiting their surface redox status as a chemical target. The T-cell-targeting fusogenic liposomes equipped with 2,2,6,6-tetramethylpiperidine (TEMP) groups neutralize reactive oxygen species protecting T cells from oxidation-induced loss of activity. Meanwhile, the production of paramagnetic 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) ... More