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Spike-mediated viral membrane fusion is inhibited by a specific anti-IFITM2 monoclonal antibody

Antiviral Res. 2023-01; 
Anna Basile , Carla Zannella , Margot De Marco , Giuseppina Sanna , Gianluigi Franci , Massimiliano Galdiero , Aldo Manzin , Vincenzo De Laurenzi , Massimiliano Chetta , Alessandra Rosati , Maria Caterina Turco , Liberato Marzullo
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The early steps of viral infection involve protein complexes and structural lipid rearrangements which characterize the peculiar strategies of each virus to invade permissive host cells. Members of the human immune-related interferon-induced transmembrane (IFITM) protein family have been described as inhibitors of the entry of a broad range of viruses into the host cells. Recently, it has been shown that SARS-CoV-2 is able to hijack IFITM2 for efficient infection. Here, we report the characterization of a newly generated specific anti-IFITM2 mAb able to impair Spike-mediated internalization of SARS-CoV-2 in host cells and, consequently, to reduce the SARS-CoV-2 cytopathic effects and syncytia formation. Further... More


IFITM2; Monoclonal antibody; SARS-CoV-2; Syncytia; Virus entry.