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pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

ACS Applied Materials & Interfaces. 2023-02; 
Shi-Hao Zhou,‡Ru-Yan Zhang,Zi-Wei You, Yong-Ke Zou, Yu Wen, Jian Wang, Dong Ding, Miao-Miao Bian, Zhi-Ming Zhang, Hong Yuan, Guang-Fu Yang, and Jun Guo
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Recombinant Proteins Omicron spike S1 protein (expressed with the mutations of A67V, del69-70, T95I, G142D, del143-145, del211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H) was purchased from GenScript (Cat: Z03729). Get A Quote


Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of great significance to enhance vaccine efficacy. In this work, we prepared a long-term stable, pH-sensitive, and biodegradable Mn3(PO4)2· 3H2O nanoparticle (nano-MnP) by simply mixing MnCl2/ NaH2PO4/Na2HPO4 solution for the first time and employed it as an immune stimulant in the bivalent COVID-19 protein vaccine comprised of wild-type S1 (S1-WT) and Omicron S1 (S1- Omicron) proteins as antigens to elicit a broad-spectrum immunity. The biological experiments indicated that the nanoMnP could effectively activate antigen-presenting cells through the cGAS−STING pathway. Compared with the convention... More


manganese phosphate, manganese adjuvant, bivalent vaccine, SARS-CoV-2, Omicron variant