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Downregulation of a transcription factor associated with resistance to Bt toxin Vip3Aa in the invasive fall armyworm

Proc Natl Acad Sci U S A . . 2023-10; 
Minghui Jin , Yinxue Shan , Yan Peng , Wenhui Wang , Huihui Zhang , Kaiyu Liu , David G Heckel , Kongming Wu , Bruce E Tabashnik , Yutao Xiao
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Transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) have revolutionized control of some major pests. However, more than 25 cases of field-evolved practical resistance have reduced the efficacy of transgenic crops producing crystalline (Cry) Bt proteins, spurring adoption of alternatives including crops producing the Bt vegetative insecticidal protein Vip3Aa. Although practical resistance to Vip3Aa has not been reported yet, better understanding of the genetic basis of resistance to Vip3Aa is urgently needed to proactively monitor, delay, and counter pest resistance. This is especially important for fall armyworm (Spodoptera frugiperda), which has evolved practical resistance to Cry... More


Bacillus thuringiensis; Spodoptera frugiperda; invasive species; myeloblastosis transcription factor; transgenic crop.