For each citation that was shared on social media (LinkedIn, Facebook, or Twitter) with the “@GenScript” tag, the author will be rewarded with a $10 Amazon gift card or 2,000 GS points.

Self−Assembling Nanovaccine Fused with Flagellin Enhances Protective Effect against Foot−and−Mouth Disease Virus

Vaccines. 2023-11; 
Chenchen Pei , Hu Dong , Zhidong Teng , Sumin Wei , Yun Zhang , Shuanghui Yin , Jianli Tang , Shiqi Sun and Huichen Guo
Products/Services Used Details Operation
Gene Synthesis Genes were codon optimized and synthesized into pSMA [23] to generate pSMA−VP1, pSMA−VP1−i301, and pSMA−VP1−i301−nFLiC by Jiangsu Genscript Biotechnology Co., Ltd Get A Quote

Abstract

Nanovaccines based on self−assembling nanoparticles (NPs) can show conformational epitopes of antigens and they have high immunogenicity. In addition, flagellin, as a biological immune enhancer, can be fused with an antigen to considerably enhance the immune effect of antigens. In improving the immunogenicity and stability of a foot−and−mouth disease virus (FMDV) antigen, novel FMDV NP antigens were prepared by covalently coupling the VP1 protein and truncated flagellin containing only N−terminus D0 and D1 (N−terminal aa 1–99, nFLiC) with self−assembling NPs (i301).The results showed that the fusion proteins VP1−i301 and VP1−i301−nFLiC can assemble into NPs with high thermal tolerance and... More

Keywords

foot−and−mouth disease; flagellin; self−assembling; nanoparticles; nanovaccine