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Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion

Phytomedicine .. 2023-09; 
Junwei Gao , Can Cao , Mingfei Shi , Shihao Hong , Shijie Guo , Jing Li , Tengxiao Liang , Ping Song , Ruodan Xu , Ning Li
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Peptide Synthesis Peptides were synthesized by Genscript Biotechnology (Nanjing, China) at > 98% purity by reverse HPLC, and their sequence was described as below. . pcDNA3.1+P2A plasmid encoding both SARS-CoV-2 M and E proteins was also generated (Genscript Biotechnology). Get A Quote
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Background: The continuous evolution of SARS-CoV-2 has underscored the development of broad-spectrum prophylaxis. Antivirals targeting the membrane fusion process represent promising paradigms. Kaempferol (Kae), an ubiquitous plant flavonol, has been shown efficacy against various enveloped viruses. However, its potential in anti-SARS-CoV-2 invasion remains obscure. Purpose: To evaluate capabilities and mechanisms of Kae in preventing SARS-CoV-2 invasion. Methods: To avoid interference of viral replication, virus-like particles (VLPs) constructed with luciferase reporter were applied. To investigate the antiviral potency of Kae, human induced pluripotent stem cells (hiPSC)-derived alveolar epithelial cell... More


COVID-19; SARS-CoV-2; antivirals; fusion; heptad repeats; kaempferol.