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LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA

Genes Genomics. 2023-09; 
Bing Dong, Cuiping Li, Xiaomeng Xu, Yan Wang, Yuewen Li, Xingmei Li
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Gene Synthesis … Therefore, further exploration of the pathogenesis of OC is necessary for the development of … LINC01123 was ligated into pcDNA vector (Genscript, Nanjing). To knockdown the … Get A Quote


background: Long non-coding RNAs (lncRNAs) play a critical role in the development of ovarian cancer (OC). objective: The study aimed to determine the role of LncRNA LINC01123 in OC bio-progression, which is upregulated in OC tissues during OC progression. methods: Bioinformatics methods, GEPIA, and qRT-PCR were used to reveal the level and correlation of LINC01123, hsa-miR-516b-5p, and VEGFA, in OC cell lines. MTT, EdU, TUNEL, and Transwell assays were performed to assess the bioactivity of OC cell. Target sites of LINC01123 and hsa-miR-516b-5p were predicted using Starbase, and the potential linkage points of VEGFA and hsa-miR-516b-5p were predicted using TargetScan. These sites and linkage points were confir... More


Hsa-miR-516b-5p, LINC01123, Long non-coding RNA, Ovarian cancer, VEGFA