| Products/Services Used | Details | Operation |
|---|---|---|
| Recombinant Proteins | In Vitro Macrophage Polarization RAW 264.7 Cells: In brief, the RAW 264.7 macrophages (AoRuisai Biotechnology Co., Ltd.) were pre-cultured with IL-4 (25 ng mL−1) (GenScript, New Jersey, USA) for 24 h to induce M2 polarization. | Get A Quote |
Metalloimmunotherapy has achieved great preclinical success against malignant tumors. Nonetheless, the limited immune cell infiltration and impaired immunogenicity within the tumor microenvironment (TME) significantly hinder its translation to clinical applications. In this study, a zinc coordination lipid nanoparticle is developed loaded with calcium peroxide hydrate (CaO2) nanoparticles and the STING agonist diABZI-2, which is termed A-CaO2-Zn-LNP. The release of Zn2+ from the A-CaO2-Zn-LNP and the calcium overload synergistically induced immunogenic cell death (ICD). In addition, CaO2 nanoparticles can consume H+ and release oxygen (O2) under acidic conditions. This treatment increased the pH and alleviated ... More
