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AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off

Nature Communications. 2024-10; 
Zhen Wang , Xiaofan Zhang , Chunyan Liu , Susan Duncan , Runlai Hang , Jing Sun , Lilan Luo , Yiliang Ding , Xiaofeng Cao
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Proteins, Expression, Isolation and Analysis or the IP-MS analysis, the nuclear proteins from Col-0 were immunoprecipitated with anti-PDCD2 and anti-IgG antibodies, separated by SDS-PAGE gel (GenScript, M00664), and subjected to Coomassie blue staining Get A Quote

Abstract

Translation, a fundamental process regulating cellular growth and proliferation, relies on functional ribosomes. As sessile organisms, plants have evolved adaptive strategies to maintain a delicate balance between growth and stress response. But the underlying mechanisms, particularly on the translational level, remain less understood. In this study, we revealed the mechanisms of AtPRMT3-RPS2B in orchestrating ribosome assembly and managing translational regulation. Through a forward genetic screen, we identified PDCD2-D1 as a suppressor gene restoring abnormal development and ribosome biogenesis in atprmt3-2 mutants. Our findings confirmed that PDCD2 interacts with AtPRMT3-RPS2B, and facilitates pre-ribosome t... More

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