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Disrupting Intracellular Homeostasis by Copper-Based Nanoinducer with Multiple Enzyme-Mimicking Activities to Induce Disulfidptosis-Enhanced Pyroptosis for Tumor Immunotherapy

ADVANCED MATERIALS. 2024-10; 
Xiao-Kang Jin , Shun-Kang Zhang , Shi-Man Zhang , Jun-Long Liang , Xiao Yan , Yan-Tong Lin , Ran Meng , Zi-Han Xu , Chuan-Jun Liu , Xian-Zheng Zhang
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Recombinant Proteins Recombinant murine IL-4 was purchased from GenScript Corporation. Recombinant murine GM-CSF were purchased from Chamot Biotechnology Co., Get A Quote

Abstract

Given the crucial role of abnormal homeostasis in tumor cells for maintaining their growth, it may be more efficient with less effort to develop anti-tumor strategies that target multiple combined mechanisms by disrupting intracellular homeostasis. Here, a copper-based nanoinducer (CGBH NNs) with multiple enzyme-like activities is designed and constructed to induce disulfidptosis-enhanced pyroptosis through disrupting multiple intracellular homeostasis for effective tumor immunotherapy. Within the tumor microenvironment (TME), CGBH NNs can disrupt intracellular glucose homeostasis and inhibit NADPH production, leading to accumulation of cystine, which further blocked the substrate and key enzyme for synthesizin... More

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