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High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses.

Antiviral Res.. 2014-04; 
Uebelhoer LS, Albariño CG, McMullan LK, Chakrabarti AK, Vincent JP, Nichol ST, Towner JS. Centers for Disease Control and Prevention, Atlanta, USA.
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Marburg virus (MARV) and Ebola virus (EBOV), members of the family Filoviridae, represent a significant challenge to global public health. Currently, no licensed therapies exist to treat filovirus infections, which cause up to 90% mortality in human cases. To facilitate development of antivirals against these viruses, we established two distinct screening platforms based on MARV and EBOV reverse genetics systems that express secreted Gaussia luciferase (gLuc). The first platform is a mini-genome replicon to screen viral replication inhibitors using gLuc quantification in a BSL-2 setting. The second platform is complementary to the first and expresses gLuc as a reporter gene product encoded in recombinant infect... More


Antiviral screen; Ebola virus; Filovirus; Luciferase; Marburg virus; Reverse genetics