Stronger in vivo inhibitory effects
Vector-based siRNA is more effective in vivo than synthetic siRNA and can work with tissue-specific promoters.
Vector-based siRNA allows the researcher to establish inducible systems using inducible vectors.
Long-term RNAi effect
Vector-based siRNA allows the researcher to obtain a stable cell line and observe the long-term effects of RNAi.
Easy to handle and renewable
Vector-based siRNA is delivered in plasmid form, which is more stable and easier to handle than synthetic siRNA. As a plasmid, it can be easily regenerated on-site.
The easy regeneration character of siRNA vectors can reduce cost in high-throughput applications, where large amount of siRNA is in need.
Viral vector-based siRNA can be used to infect primary cell lines for gene therapy purposes.
Easy enrichment of knock-down cells
Vectors can be equipped with antibiotic resistance genes, allowing the easy removal of untransfected cells.
Please read more about siRNA technology.