Synthetic Biology applies engineering principles to biological systems, by designing and building new DNA parts to turn cells into useful machines to produce biofuels, medicines, and other economically important organic materials. Gene Synthesis has revolutionized synthetic biology through the de novo chemical synthesis of new DNA molecules encoding novel or optimized proteins, metabolic circuits, or even whole genomes. Gene synthesis expands the possibilities for custom-designing DNA sequences for specific applications in a more powerful and efficient manner than older recombinant DNA technology that required naturally-occurring template DNA as a starting material. As a pioneer in gene synthesis technology and a leader among synthetic biology companies worldwide, GenScript is proud to enable a new era of synthetic biology that will yield new insights into the fundamental principles of life as well as new advances in energy, medicine, and other economically important endeavors.
Synthetic Biology Research Areas
GenScript Services for Synthetic Biology Research
- GenPlus High-Throughput Gene Synthesis: next-gen technology, starting at $0.23/bp
- GenBrick DNA Building Blocks for Synthetic Biology: 8-15kb long DNA constructs in just 23 business days
- GenCRISPR genome editing services, including free all-in-one vectors and a free online gRNA design tool
- Antibody Library and Phage Display Services
Synthetic Biology Webinars
- Building a Synthetic Eukaryotic Genome: Design, Construction and Application
- Gene variant libraries: design, construction, and research applications
- Codon optimization: Why & how to design DNA sequences for optimal soluble protein expression
- Design high specificity CRISPR/Cas9 gRNAs: principles and tools
- See the full list of Upcoming and Archived Webinars
Featured Publications in Synthetic Biology
- Lentini R, et al. Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour. Nature Commun. 2014 May 30;5:4012. Free Full Text
- Nunes S. et al. A Synthetic Biology Approach For a Vaccine Platform Against Known and Newly Emerging Serotypes of Bluetongue Virus. J Virol. 2014 Nov;88(21):12222-32. Free Full Text
- Angermayr SA, et al. Exploring metabolic engineering design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803. Biotechnol Biofuels. 2014 Jun 26;7:99. Free Full Text
- Kang MK et al. Synthetic biology platform of CoryneBrick vectors for gene expression in Corynebacterium glutamicum and its application to xylose utilization. Appl Microbiol Biotechnol. 2014 Jul;98(13):5991-6002. Full Text
- Bi C et al. Development of a broad-host synthetic biology toolbox for ralstonia eutropha and its application to engineering hydrocarbon biofuel production. Microb Cell Fact. 2013 Nov 13;12:107. Free Full Text
- Lakshmi S. et al. Gene gymnastics: Synthetic biology for baculovirus expression vector system engineering. Bioengineered. 2013 Sep-Oct;4(5):279-87. Free Full Text
Synthetic HCV genome engineered with mutations enabling in vitro infectivity:
an important new tool to support HCV research and vaccine development
As HCV-related liver disease claims hundreds of thousands of lives each year, Hepatitis C Virus research has thus far been hampered by a lack of infectious cell-culture systems to support basic and translational research including vaccine development. A new paper in J.Virology reports a breakthrough in developing in vitro infectious clones for the most common HCV strains. These researchers synthesized HCV-1 and H77 prototype genomes containing specific mutations that enable infectious particle production in cell culture.
|Li et al. Efficient infectious cell culture systems of the hepatitis C virus prototype strains HCV-1 and H77. J Virol. 2014 Oct 29. pii: JVI.02877-14. Read Free Full Text|
Paper-based gene circuits allow an Ebola sensor to be developed in a single day
A new paper in Cell reports a breakthrough technique to bring synthetic biology out of the lab. By freeze-drying biological components and embedding them in paper, researchers can rapidly create new cell-free transcription-based detectors that can be used anywhere, without relying on laboratories with sterile cell culture facilities. As a proof-of-principle, they developed a paper-based Ebola virus detector in a single day.
|Pardee et al. Paper-Based Synthetic Gene Networks Cell. 2014 Nov 6. 159(4):940–954. Read Free Full Text|
Building bigger DNA: 3D DNA structures on nanometer scale
In addition to its familiar function of encoding genetic information, DNA is a valuable biomaterial for fabricating customized nanostructures. DNA's ability to self-assemble into precise 3-D structures used in applications from drug delivery to electronic components. A new study reports the creation of scaffolded DNA origami structures far larger than previously described, thanks to two major technological improvements: the use of longer DNA scaffolds and the use of a new chip-based platform for inexpensive synthesis of 1600 DNA sequences serving as staples.
Marchi et al. Toward larger DNA origami. Nano Lett. 2014 Oct 8;14(10):5740-7. Read Free Full Text
Quotation and Ordering for synthetic biology services
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The products and services in this section are Research Use Only. Not for use in human clinical diagnostics or therapeutics or in vitro diagnostic procedures.