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antibody affinity maturation

Antibody Affinity Maturation Service

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Antibody Affinity Maturation Service (Cat. No.: SC1574)

Service Includes Deliverable Timeline
Antibody sequencing and sequence analysis
  • Antibody sequence, report of sequence analysis
24 weeks
Library design and construction
  • Library plasmid and glycerol stock, Report of library development
Phage display and FASEBA screening
  • Top five Fab candidates; Report of screening
Antibody production and characterization
  • Final report and purified antibody

The following is GenScript's standard affinity maturation service procedure:

Affinity_ranking
  • Please find out more for FASEBA technology here FASEBA.pdf
  • GenScript offers our customers a one-stop solution for all outsourcing needs, providing comprehensive upstream and downstream services of monoclonal antibody sequencing service.

    Key Features:

    • Proprietary FASEBA technology for guaranteed protein stability
    • Affinity maturated to at least low nM or improved 10 fold
    • Affinity assessed with BIAcore T200
    • Expression level evaluated

    Affinity is a key parameter of an antibody and often defines its functions and efficacy. Antibodies generated with hybridoma technology usually have a relatively high affinity but this affinity may still not suffice the need of a therapeutic antibody. GenScript's Antibody Affinity Maturation Service (Cat. No.: SC1574) can increase the affinity to an ideal level.


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