PKC ε Antibody, pAb, Rabbit

Protein kinase C (PKC), a family of serine/threonine kinases, plays an important role in the growth factor signal transduction pathway. The PKC family consists of at least ten members, divided into three subgroups: classical PKCs (alpha, beta I, beta II, gamma), novel PKCs (delta, epsilon, eta, theta), and atypical PKCs (zeta, iota/lambda). Accumulating data suggest that various PKC isoforms participate in the regulation of cell proliferation, differentiation, survival and death. PKC epsilon (PKCε) is a calcium-independent and phorbolester/diacylglycerol-sensitive serine/threonine kinase. PKCε is the only PKC isozyme that has been shown to behave as an oncoprotein. The Rabbit anti-PKC ε antibody is developed in rabbit using a synthetic peptide, KGFSYFGEDLMP, corresponding to a distinct C terminal region from rat PKC ε conjugated to KLH. This polyclonal antibody is highly purified from rabbit antiserum by immunoaffinity chromatography and is supplied as a 40 μg aliquot at a concentration of 1 mg/ml in PBS, pH 7.4, containing 0.02% sodium azide.