Catalog Products » Prohibitin Antibody, pAb, Rabbit
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Prohibitin Antibody, pAb, Rabbit

*This product has been discontinued!*
Prohibitin is believed to be a negative regulator of cell proliferation and may also act as a tumor suppressor. Mutations in prohibitin have been linked to sporadic breast cancer. Prohibitin inhibits DNA synthesis and plays a role in proliferation regulation. As yet, it is unclear if it is the protein or the mRNA that exhibits these effects. Prohibitin may play a role in regulating mitochondrial respiration activity and aging. Prohibitin is located at the inner mitochondrial membrane and is widely expressed in various tissues.GenScript Rabbit Anti-Prohibitin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 50-100 of human prohibitin protein (Swiss Prot: P35232).
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Overview
Specificity GenScript Rabbit Anti-Prohibitin Polyclonal Antibody detects endogenous levels of human prohibitin protein.
Host Species Rabbit
Immunogen Synthetic peptide (KLH-coupled) derived from within residues 50-100 of human prohibitin (Swiss Prot: P35232)
Species Reactivity Human, mouse. This product has not yet been tested with other species.
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Properties
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography
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Background
Target Background Prohibitin is believed to be a negative regulator of cell proliferation and may also act as a tumor suppressor. Mutations in prohibitin have been linked to sporadic breast cancer. Prohibitin inhibits DNA synthesis and plays a role in proliferation regulation. As yet, it is unclear if it is the protein or the mRNA that exhibits these effects. Prohibitin may play a role in regulating mitochondrial respiration activity and aging. Prohibitin is located at the inner mitochondrial membrane and is widely expressed in various tissues.
GenScript Rabbit Anti-Prohibitin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 50-100 of human prohibitin protein (Swiss Prot: P35232).
Synonyms Rabbit Anti Prohibitin Polyclonal Antibody;
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Citations
Cynthia Picard, et al. Nuclear Accumulation of Prohibitin 1 in Osteoarthritic Chondrocytes Down-Regulates PITX1 Expression. Arthritis Rheum. (2013-04)