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TPMT Antibody, pAb, Rabbit

*This product has been discontinued!*
TPMT (thiopurine S-methyltransferase) is an enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including the immunosuppressant azathioprine (AZA) and the antineoplastic agents 6-mercaptopurine (6MP) and 6-thioguanine (6TG). The enzyme is also involved in the normal metabolic inactivation of thiopurine drugs. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs.GenScript Rabbit Anti-TPMT Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 200-250 of human TPMT protein (Swiss Prot: P51580).
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Overview
Specificity GenScript Rabbit Anti-TPMT Polyclonal Antibody detects human TPMT protein.
Host Species Rabbit
Immunogen Synthetic peptide (KLH-coupled) within residues 200-250 of human TPMT protein (Swiss Prot: P51580)
Species Reactivity Human. This product has not yet been tested with other species.
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Properties
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography
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Background
Target Background TPMT (thiopurine S-methyltransferase) is an enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including the immunosuppressant azathioprine (AZA) and the antineoplastic agents 6-mercaptopurine (6MP) and 6-thioguanine (6TG). The enzyme is also involved in the normal metabolic inactivation of thiopurine drugs. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs.
GenScript Rabbit Anti-TPMT Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 200-250 of human TPMT protein (Swiss Prot: P51580).
Synonyms Rabbit Anti TPMT Polyclonal Antibody;
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