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Histone H4 Antibody (Acetyl-K12), pAb, Rabbit

*This product has been discontinued!*
Histone H4 is a core component of nucleosome. It facilitates nucleosome wrapping and DNA compacting into chromatin, thereby limiting the DNAs accessibility to the cellular machineries for which DNA is required as a template. Histones play a central role in transcription regulation, DNA repair / replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, of which the process is called the histone code, and nucleosome remodeling.GenScript Rabbit Anti-Histone H4 (Acetyl-K12) Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic acetylpeptide corresponding to residues surrounding Lys12 of human Histone H4 (Swiss Prot: Q99525).
A01310
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Overview
Specificity GenScript Rabbit Anti-Histone H4 (Acetyl-K12) Polyclonal Antibody detects endogenous levels of human and mouse histone H4 only when acetylated at Lys12. It is predicted to react with rat based on sequence homology.
Host Species Rabbit
Immunogen KLH-coupled synthetic acetylpeptide corresponding to residues surrounding Lys12 of human Histone H4 (Swiss Prot: Q99525).
Species Reactivity Human and mouse. This product has not yet been tested with other species.
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Properties
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography using acetylpeptide, cross-adsorbed with corresponding non-acetylpeptide
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Background
Target Background Histone H4 is a core component of nucleosome. It facilitates nucleosome wrapping and DNA compacting into chromatin, thereby limiting the DNAs accessibility to the cellular machineries for which DNA is required as a template. Histones play a central role in transcription regulation, DNA repair / replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, of which the process is called the histone code, and nucleosome remodeling.

GenScript Rabbit Anti-Histone H4 (Acetyl-K12) Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic acetylpeptide corresponding to residues surrounding Lys12 of human Histone H4 (Swiss Prot: Q99525).
Synonyms Rabbit Anti-Acetyl-Histone H4 (Lys12) pAb;
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