HSP27 Antibody, pAb, Rabbit

*This product has been discontinued!*

HSP27 is one member of the sHSP (small heat shock protein) family, of which the common functions include chaperone activity, inhibition of apoptosis, regulation of cell development, and cell differentiation. HSP27 protein interferes with the activation of cytochrome c/Apaf-1/dATP complex and therefore inhibits the activation of procaspase-9. Phosphorylation of HSP27 inhibits Daxx apoptotic protein and prevents the association of Daxx with Fas and Ask1. In addition, HSP27 prevents the formation of non-covalent filament/filament interactions of the intermediate filaments and protects actin filaments from fragmentation via its interaction with actin and intermediate filaments. HSP27 speeds up the degradation of irreversibly denatured proteins and enhances the activation of the NF-κB pathway. It is possible that HSP27 plays a crucial role in growth termination.GenScript Rabbit Anti-HSP27 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 180-230 of human HSP27. (Swiss Prot: P04792).

Cat. No.	A01378
Size	Buy in bulk

Ask us a question

Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-HSP27 Polyclonal Antibody detects endogenous levels of human HSP27.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from within residues 180-230 of human HSP27. (Swiss Prot: P04792).
Species Reactivity	Human

Back

Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

Back

Background

Target Background

HSP27 is one member of the sHSP (small heat shock protein) family, of which the common functions include chaperone activity, inhibition of apoptosis, regulation of cell development, and cell differentiation. HSP27 protein interferes with the activation of cytochrome c/Apaf-1/dATP complex and therefore inhibits the activation of procaspase-9. Phosphorylation of HSP27 inhibits Daxx apoptotic protein and prevents the association of Daxx with Fas and Ask1. In addition, HSP27 prevents the formation of non-covalent filament/filament interactions of the intermediate filaments and protects actin filaments from fragmentation via its interaction with actin and intermediate filaments. HSP27 speeds up the degradation of irreversibly denatured proteins and enhances the activation of the NF-κB pathway. It is possible that HSP27 plays a crucial role in growth termination.

GenScript Rabbit Anti-HSP27 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 180-230 of human HSP27. (Swiss Prot: P04792).

Synonyms

Rabbit Anti-HSP27 pAb;

Back