FOXA1 Antibody, pAb, Rabbit

*This product has been discontinued!*

Forkhead box protein A1 (FOXA1) is an evolutionarily conserved winged helix transcription factor that was traditionally considered to be involved in embryonic development and cell differentiation. It plays a pro-apoptotic role by inhibiting the expression of anti-apoptotic gene bcl2. FOXA1 plays a critical role in defining the ERalpha cistrome in MCF7 cells. It may serve as a therapeutic target for breast cancer. Despite the ability of FOXA1 to bind nucleosomes, its differential binding to chromatin sites is dependent on the distribution of histone H3 lysine 4 dimethylation. In addition, FOXA1 regulate multiple phases of midbrain dopaminergic neuron development.GenScript Rabbit Anti-FOXA1 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 200-250 of human FOXA1 (Swiss Prot: P55317).

Cat. No.	A01389
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-FOXA1 Polyclonal Antibody detects endogenous levels of human and mouse FOXA1 protein. It is predicted to react with rat FOXA1 protein according to sequence homology. This antibody also recognizes FOXA3.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide within from residues 200-250 of human FOXA1 (Swiss Prot: P55317).
Species Reactivity	Human and mouse. This product has not been tested with other species yet.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

Forkhead box protein A1 (FOXA1) is an evolutionarily conserved winged helix transcription factor that was traditionally considered to be involved in embryonic development and cell differentiation. It plays a pro-apoptotic role by inhibiting the expression of anti-apoptotic gene bcl2. FOXA1 plays a critical role in defining the ERalpha cistrome in MCF7 cells. It may serve as a therapeutic target for breast cancer. Despite the ability of FOXA1 to bind nucleosomes, its differential binding to chromatin sites is dependent on the distribution of histone H3 lysine 4 dimethylation. In addition, FOXA1 regulate multiple phases of midbrain dopaminergic neuron development.

GenScript Rabbit Anti-FOXA1 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 200-250 of human FOXA1 (Swiss Prot: P55317).

Synonyms

Rabbit Anti-FOXA1 pAb;

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