TrkA Antibody, pAb, Rabbit

*This product has been discontinued!*

TrkA is one member of Trk receptor tyrosine kinases family that consists of TrkA, TrkB, and TrkC. TrkA plays an important role in proliferation and maturation of the nervous system. TrkA phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. TrkA kinase activity depends on phosphorylation of residues Tyr674/675 within catalytic domain. TrkA signals growth arrest and differentiation of cells originating from the neural crest, and can serve as a prognostic marker in neuroblastomas.GenScript Rabbit Anti-TrkA Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 350-400 of human TrkA (Swiss Prot: P04629).

Cat. No.	A01403
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-TrkA Polyclonal Antibody detects human TrkA protein. It is predicted to react with mouse and rat according to sequence homology.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide within residues 350-400 of human TrkA (Swiss Prot: P04629).
Species Reactivity	Human. This product has not been tested with other species yet.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

TrkA is one member of Trk receptor tyrosine kinases family that consists of TrkA, TrkB, and TrkC. TrkA plays an important role in proliferation and maturation of the nervous system. TrkA phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. TrkA kinase activity depends on phosphorylation of residues Tyr674/675 within catalytic domain. TrkA signals growth arrest and differentiation of cells originating from the neural crest, and can serve as a prognostic marker in neuroblastomas.

GenScript Rabbit Anti-TrkA Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 350-400 of human TrkA (Swiss Prot: P04629).

Synonyms

Rabbit Anti-TrkA pAb;

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