Annexin II Antibody, pAb, Rabbit

*This product has been discontinued!*

Annexin II is one member of the annexin family of calcium-dependent phospholipids binding proteins. It plays a role in the regulation of membrane and actin dynamics particularly in the endocytic pathway. A tyrosine phosphorylation switch in Annexin II triggers Rho/ROCK- dependent and actin-mediated changes in cell morphology associated with the control of cell adhesion. It may play roles in p53 induced apoptosis and it is also involved in regulation of cell proliferation. Annexin II is binding partner of SHP2 and the binding of SHP2 with Annexin II is affected by EGF stimulation, extracellular calcium levels, and the levels of HSP70. GenScript Rabbit Anti-Annexin II Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 180-230 of human Annexin II protein (Swiss Prot: P07355).

Cat. No.	A01471
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-Annexin II Polyclonal Antibody detects endogenous levels of human Annexin II. Predicted to react with rat and mouse Annexin II according to sequence homology. Positive Control: Hela and HepG2.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide within residues 180-230 of human Annexin II protein (Swiss Prot: P07355).
Species Reactivity	Human. Reactivity to other species is not tested yet.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

Annexin II is one member of the annexin family of calcium-dependent phospholipids binding proteins. It plays a role in the regulation of membrane and actin dynamics particularly in the endocytic pathway. A tyrosine phosphorylation switch in Annexin II triggers Rho/ROCK- dependent and actin-mediated changes in cell morphology associated with the control of cell adhesion. It may play roles in p53 induced apoptosis and it is also involved in regulation of cell proliferation. Annexin II is binding partner of SHP2 and the binding of SHP2 with Annexin II is affected by EGF stimulation, extracellular calcium levels, and the levels of HSP70.
GenScript Rabbit Anti-Annexin II Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 180-230 of human Annexin II protein (Swiss Prot: P07355).

Synonyms

Annexin A2 antibody;

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Citations

1. LaneRosemary, et al. Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping. Commun Biol. (2019)