67kDa Laminin Receptor Antibody, pAb, Rabbit

*This product has been discontinued!*

GenScript 67kDa Laminin Receptor Antibody, pAb, Rabbit detects endogenous levels of human 67kDa Laminin Receptor. Positive Control: Hela, HEK293 and MCF-7_x000D_

Cat. No.	A01638
Size	Buy in bulk

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Overview Applications Properties Background Bottom Notes

Overview

Specificity	GenScript 67kDa Laminin Receptor Antibody, pAb, Rabbit detects endogenous levels of human 67kDa Laminin Receptor. Positive Control: Hela, HEK293 and MCF-7
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from C-terminal of 67kDa Laminin Receptor (Swiss Prot: P08865)
Species Reactivity	Human. Reactivity to other species is not tested yet.
Conjugate	Unconjugated

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Applications

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

Application	Recommended Usage
Immunohistochemistry	5-10 µg/ml
Western Blot	0.5-1 µg/ml
Immunoprecipitation (IP)	2-10 µg/mg of lysate
Other applications	User-optimized

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Properties

Form	Lyophilized
Storage Buffer	lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/mL.
Storage Instructions	The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Purification	Affinity chromatography
Isotype	Rabbit IgG
Clonality	Polyclonal
Clone ID	Not applicable

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Background

Target Background

67kDa Laminin Receptor has multiple biological activities which are mediated through its interaction with specific cell membrane receptors. The receptor is required for the assembly and/or stability of the 40S ribosomal subunit. 67kDa Laminin Receptor participates in the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. It also functions as a cell surface receptor for laminin and plays a role in cell adhesion to the basement membrane in the consequent activation of signaling transduction pathways. Overexpression of 67kDa Laminin Receptor is reportedly an independent prognostic factor in breast cancer and correlates with the dissemination of the tumor cells in bone marrow.GenScript 67kDa Laminin Receptor Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of 67kDa Laminin Receptor (Swiss Prot: P08865).

Synonyms

LAMR1 Antibody, pAb, Rabbit;

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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.