Torsin A Antibody, pAb, Rabbit

*This product has been discontinued!*

Torsin A is a member a superfamily of ATPases based on homology and configurational alignment. It is predominantly localized in the contiguous lumen of the nucleaenvelope (NE) and endoplasmic reticulum (ER). It plays an important role in maintaining the integrity of the nuclear envelope. Torsin A is associated with lamin-associated polypeptide 1 (TOR1AIP1) in the inner nuclear membrane (INM) of the NE and with LULL1 (TOR1AIP2) in the ER/NE, as well as with conventional kinesin light chain 1 (KLC1), vimentin and actin in the cytoplasm. It interacts with a novel class of transmembrane proteins that are localized in different subdomains of the ER system, either or both of which may play a role in the pathogenesis of DYT1 dystonia.GenScript Torsin A Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 40-90 of human Torsin A (Swiss Prot: O14656).

Cat. No.	A01659
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Torsin A Antibody, pAb, Rabbit detects endogenous levels of human, mouse and rat Torsin A protein. Positive Control: U251, Mouse brain and Rat brain
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide within residues 40-90 of human Torsin A (Swiss Prot: O14656)
Species Reactivity	Human, mouse and rat. Reactivity to other species is not tested yet.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

Torsin A is a member a superfamily of ATPases based on homology and configurational alignment. It is predominantly localized in the contiguous lumen of the nucleaenvelope (NE) and endoplasmic reticulum (ER). It plays an important role in maintaining the integrity of the nuclear envelope. Torsin A is associated with lamin-associated polypeptide 1 (TOR1AIP1) in the inner nuclear membrane (INM) of the NE and with LULL1 (TOR1AIP2) in the ER/NE, as well as with conventional kinesin light chain 1 (KLC1), vimentin and actin in the cytoplasm. It interacts with a novel class of transmembrane proteins that are localized in different subdomains of the ER system, either or both of which may play a role in the pathogenesis of DYT1 dystonia.
GenScript Torsin A Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 40-90 of human Torsin A (Swiss Prot: O14656).

Synonyms

DQ2 Antibody, pAb, Rabbit;

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