Catalog Products » Bcl 2 L1 Antibody, mAb, Rabbit
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Bcl 2 L1 Antibody, mAb, Rabbit

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
$210.00
A02835-50

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Overview
Specificity This product is specific to Bcl 2 L1
Host Species Rabbit
Immunogen A synthesized peptide derived from human Bcl 2 L1
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated
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Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunohistochemistry (IHC) 1:100-1:200
Immunoprecipitation (IP) 1:20-1:50
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Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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Bcl 2 L1 Antibody, MAb, Rabbit

Western blot analysis of Bcl-XL expression in (1) Ramos cell lysate; (2) K562 cell lysate. »

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Background
Target Background Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Synonyms Apoptosis regulator Bcl-X; BLC2L; Bcl-2-like 1 protein bclxl; BCL2L; BCL2L1; BCLX;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.