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p38 MAPK Antibody, mAb, Rabbit

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors.RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery.
$210.00
A02870-50

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Overview
Specificity This product is specific to p38 MAPK
Host Species Rabbit
Immunogen A synthesized peptide derived from human p38 MAPK
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated
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Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50-1:200
Immunoprecipitation (IP) 1:20-1:50
Flow Cytometry 1:20-1:100
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Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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P38 MAPK Antibody, MAb, Rabbit

Western blot analysis of p38 MAPK expression in (1) HeLa cell lysate; (2) Jurkat cell lysate; (3) NIH/3T3 cell lysate; (4) Mouse heart lysate; (5) Mouse kidney lysate; (6) Rat heart lysate; (7) Rat kidney lysate; (8) C6 cell lysate; (9) PC12 cell lysate. »

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Background
Target Background Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors.RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery.
Synonyms MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A;EXIP; Mxi2;PRKM14; PRKM15; RK; p38; p38ALPHA;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.