Catalog Products » p-Focal adhesion kinase 1 (Y397) Antibody, mAb, Rabbit
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p-Focal adhesion kinase 1 (Y397) Antibody, mAb, Rabbit

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development.
$210.00
A02969-50

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Overview
Specificity This product is specific to p-Focal adhesion kinase 1 (Y397)
Host Species Rabbit
Immunogen A synthesized peptide derived from human Focal adhesion kinase 1 around the phosphorylation site of Y397
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated
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Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50-1:200
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Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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P-Focal Adhesion Kinase 1 (Y397) Antibody, MAb, Rabbit

Western blot analysis of Phospho-FAK (Y397) expression in EGF treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. »

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Background
Target Background Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development.
Synonyms EC 2.7.10.2; FADK 1; FAK1; Focal adhesion kinase 1; PTK2; Protein- tyrosine kinase 2; pp125FAK;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.