Catalog Products » BTK Antibody, mAb, Rabbit
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BTK Antibody, mAb, Rabbit

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation.After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members.
$210.00
A03116-50

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Overview
Specificity This product is specific to BTK
Host Species Rabbit
Immunogen A synthesized peptide derived from human BTK
Species Reactivity Human
Conjugate Unconjugated
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Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunoprecipitation (IP) 1:20-1:50
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Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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BTK Antibody, MAb, Rabbit

Western blot analysis of BTK expression in (1) Daudi cell lysate; (2) Ramos cell lysate; (3) K562 cell lysate. »

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Background
Target Background Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation.After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members.
Synonyms AGMX1; Tyrosine-protein kinase BTK; BTK; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; ATK; BPK;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.