Catalog Products » Integrin beta 4 Antibody, mAb, Rabbit
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Integrin beta 4 Antibody, mAb, Rabbit

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.
$210.00
A03587-50

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Overview
Specificity This product is specific to Integrin beta 4
Host Species Rabbit
Immunogen A synthesized peptide derived from human Integrin beta 4
Species Reactivity Human; Mouse
Conjugate Unconjugated
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Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunohistochemistry (IHC) 1:100-1:200
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Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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Integrin Beta 4 Antibody, MAb, Rabbit

Western blot analysis of Integrin beta 4 expression in (1) SW480 cell lysate; (2) Mouse spleen lysate. »

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Background
Target Background Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.
Synonyms CD104; gp150; Integrin beta 4 subunit; ITG B4; ITGB 4; Itgb4;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.