GMP Anti-Human CD3 Antibody (OKT3), mAb, Mouse

*This product has been discontinued!*

This product is specific for Human CD3

Cat. No.	GMPA02199
Size	Buy in bulk

Ask us a question

Overview Applications Properties Quality Control Specifications Background Bottom Notes

Overview

Specificity	This product is specific for Human CD3
Host Species	Mouse
Immunogen	Recombinant Human CD3
Conjugate	Unconjugated

Back

Applications

ex vivo cell culture process; Flow cytometry

Back

Properties

Form	Liquid
Storage Buffer	Supplied in 10 mM Sodium Citrate, 150 mM NaCl, 0.02 mg/ml Polysorbate 80, pH 5.0
Concentration	5 mg/ml
Storage Instructions	The product remains stable at -70 ± 10 °C. Avoid repeated freeze-thaw cycles. Please refer to the COA for specific expiry date.
Isotype	Mouse IgG2a
Clonality	Monoclonal
Clone ID	OKT3

Back

Quality Control Specifications

Appearance	Clear, colorless liquid
pH	5.0 ± 0.5
Concentration	5.0 ± 0.5 mg/ml tested by A280 nm
Purity	≥ 95.0% as analyzed by SEC-HPLC
Sequence	The coverage of the light chain and heavy chain sequence was 100% consistent with the theoretical amino acid sequence by mass spectrometry (MS)
Residual HCP	≤ 100.0 ng/mg by ELISA method
Residual HCD	≤ 10.0 pg/mg by quantitative PCR method
Residual Protein A	≤ 10.0 ng/mg by ELISA method
Endotoxin Level	< 0.1 EU/mg by gel clotting method
Sterility	No growth
Reactivity	Qualified

Back

Background

Target Background

CD3 is a member of the immunoglobulin superfamily, expressed on T cells. It is composed of four distinct chains (ε, γ, δ, ζ). CD3 antigen can form a complex with the T cell receptor (TCR) to generate an activation signal in T cells, which plays an important role in the transduction of TCR signal and the activation of both cytotoxic T cells (CD8 + naïve T cells) and T helper cells (CD4+ naïve T cells).

Back

For laboratory research and ex vivo cell isolation and culture applications. Direct human use, including taking orally and injection and clinical use are forbidden.