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GPCR & Ion Channel Stable Cell Lines

GenScript offers a large product portfolio covering GPCR and ion channel stable cell lines, as well as well other products made using these stable cell lines: Ready-to-UseTM Frozen Cells and Membrane Preparations. In addition, GenScript offers Custom Stable Cell Line Service upon your specifications.

GPCR Stable Cell Lines

Class
Ligand Type
GPCR Family
Receptor
Cell Line
Cat. No.
A
 Non-peptide Acetylcholine (muscarinic) M1 / CHRM1 CHO-K1/M1
A
 Non-peptide Acetylcholine (muscarinic) M2 / CHRM2 CHO-K1/M2/Gα15
A
 Non-peptide Acetylcholine (muscarinic) M3 / CHRM3 CHO-K1/M3
A
 Non-peptide Acetylcholine (muscarinic) M4 / CHRM4 CHO-K1/M4/Gα15
A
 Non-peptide Acetylcholine (muscarinic) M5 / CHRM5 CHO-K1/M5
A
 Non-peptide Adenosine ADORA1 CHO-K1/ADORA1/Gα15
A
 Non-peptide Adenosine ADORA1 293/ADORA1/Gα15
A
 Non-peptide Adenosine ADORA2A CHO-K1/ADORA2A/Gα15
A
 Non-peptide Adenosine ADORA2B CHO-K1/ADORA2B/Gα15
A
 Non-peptide Adenosine ADORA3 CHO-K1/ADORA3/Gqi5
A
 Non-peptide Adrenoceptors ADRA1A CHO-K1/ADRA1A
A
 Non-peptide Adrenoceptors ADRA1B CHO-K1/ADRA1B
A
 Non-peptide Adrenoceptors ADRA1D CHO-K1/ADRA1D
A
 Non-peptide Adrenoceptors ADRA2A CHO-K1/ADRA2A/Gα15
A
 Non-peptide Adrenoceptors ADRA2B CHO-K1/ADRA2B/Gqi5
A
 Non-peptide Adrenoceptors ADRA2C CHO-K1/ADRA2C/Gα15
A
 Non-peptide Adrenoceptors ADRB1 CHO-K1/ADRB1/Gα15
A
 Non-peptide Adrenoceptors ADRB2 CHO-K1/ADRB2/Gα15
A
 Non-peptide Adrenoceptors ADRB3 293/ADRB3/CRE-Luc
A
 Peptide Anaphylotoxin C5a / C5AR1 CHO-K1/C5a/Gα15
A
 Peptide Angiotensin AT1 293T/AT1
A
 Peptide Angiotensin AT1 HEK293/AT1
A
 Peptide Apelin AGTRL1 CHO-K1/AGTRL1/Gα15
A
 Non-peptide Bile acid GPBAR1 CHO-K1/GPBAR1
A
 Peptide Bombesin BB1 / NMBR CHO-K1/BB1
A
 Peptide Bombesin BB2 / GRPR CHO-K1/BB2
A
 Peptide Bombesin BB3 / BRS3 CHO-K1/BB3
A
 Peptide Bradykinin B1 / BDKRB1 CHO-K1/B1/Gα15
M00482
A
 Peptide Bradykinin B2 / BDKRB2 CHO-K1/B2/Gα15
A
 Non-peptide Cannabinoid CB1 / CNR1 CHO-K1/CB1/Gα15
A
 Non-peptide Cannabinoid CB2 / CNR2 CHO-K1/CB2
A
 Peptide Chemoattractant ChemR23 / CMKLR1 CHO-K1/CMKLR1/Gα15
A
 Peptide Cholecystokinin CCKA CHO-K1/CCKA/Gα15
A
 Peptide Cholecystokinin CCKB CHO-K1/CCKB
A
 Non-peptide Dopamine D1 / DRD1 CHO-K1/D1
A
 Non-peptide Dopamine D2 / DRD2 CHO-K1/D2/Gα15
A
 Non-peptide Dopamine D2S / DRD2S CHO-K1/D2S/Gα15
A
 Non-peptide Dopamine D4 / DRD4 293/D4
M00477
A
 Non-peptide Dopamine D5 / DRD5 CHO-K1/D5/Gα15
A
 Peptide Endothelin EDNRA CHO-K1/EDNRA
A
 Peptide Endothelin EDNRB CHO-K1/EDNRB
A
 Non-peptide Free Fatty Acid FFA1 / GPR40 CHO-K1/FFA1/Gα15
A
 Non-peptide Free Fatty Acid FFA2 / GPR43 CHO-K1/FFA2/Gα15
A
 Peptide Galanin GAL1 CHO-K1/GAL1/Gα15
A
 Peptide Galanin GAL2 CHO-K1/GAL2
A
 Peptide Ghrelin GHSR CHO-K1/GHSR
A
 Peptide Gonadotropin-releasing Hormone GNRHR CHO-K1/GNRHR/Gα15
A
 Non-peptide Histamine H1 293/H1
A
 Non-peptide Histamine H2 CHO-K1/H2/Gα15
A
 Non-peptide Histamine H3 CHO-K1/H3/Gα15
A
 Non-peptide Histamine H4 CHO-K1/H4/Gα15
A
 Peptide KiSS1-derived Peptide KiSS1 / GPR54 CHO-K1/KiSS1
A
 Non-peptide Leukotriene CysLT1 CHO-K1/CysLT1/Gα15
A
 Non-peptide Leukotriene CysLT2 CHO-K1/CysLT2
A
 Non-peptide Leukotriene LTB4 CHO-K1/LTB4/Gα15
A
 Non-peptide Leukotriene OXE / OXER1 CHO-K1/OXE-Flag/Gα15
M00488
A
 Non-peptide Lysophospholipid EDG4 / LPA2 RH7777/EDG4
A
 Non-peptide Lysophospholipid EDG6 / S1P4 RH7777/EDG6
M00465
A
 Peptide Melanin-concentrating Hormone MCH1 293/MCH1
A
 Peptide Melanin-concentrating Hormone MCH2 CHO-K1/MCH2
A
 Peptide Melanocortin MC2 CHO-K1/MC2/Gα15
A
 Peptide Melanocortin MC3 CHO-K1/MC3/Gα15
A
 Peptide Melanocortin MC3 293/MC3/CRE-Luc
A
 Peptide Melanocortin MC4 CHO-K1/MC4/Gα15
A
 Peptide Melanocortin MC5 CHO-K1/MC5/Gα15
A
 Peptide Melatonin MT1 / MTNR1A CHO-K1/MT1/Gα15
A
 Peptide Melatonin MT2 / MTNR1B CHO-K1/MT2/Gα15
A
 Peptide Motilin MTLR CHO-K1/MTLR/Gα15
A
 Peptide Neuromedin U NMU1 CHO-K1/NMU1
A
 Peptide Neuromedin U NMU2 293T/NMU2
A
 Peptide Neuropeptide B/W NPBW1 / GPR7 CHO-K1/NPBW1/Gα15
A
 Peptide Neuropeptide FF NPFF1 / GPR147 CHO-K1/NPFF1/Gα15
A
 Peptide Neuropeptide FF NPFF2 / GPR74 CHO-K1/NPFF2/Gα15
A
 Peptide Neuropeptide S NPS1a CHO-K1/NPS1a/Gα15
A
 Peptide Neuropeptide S NPS1b CHO-K1/NPS1b/Gα15
A
 Peptide Neuropeptide Y NPY1 CHO-K1/NPY1/Gα15
M00192
A
 Peptide Neuropeptide Y NPY1 293/NPY1
M00430
A
 Peptide Neuropeptide Y NPY2 CHO-K1/NPY2/Gqi5
A
 Peptide Neuropeptide Y NPY4 / PPYR1 CHO-K1/NPY4/Gα15
A
 Peptide Neurotensin NTS1 CHO-K1/NTS1
A
 Non-peptide Nicotinic Acid NIACR1 / GPR109A CHO-K1/NIACR1/Gα15
A
 Peptide N-Formyl Peptide FPR1 CHO-K1/FPR1/Gα15
A
 Peptide N-Formyl Peptide FPRL1 CHO-K1/FPRL1/Gα15
A
 Peptide Opioid OPRD1 CHO-K1/OPRD1/Gα15
A
 Peptide Opioid OPRK1 CHO-K1/OPRK1/Gα15
A
 Peptide Opioid OPRL1 CHO-K1/OPRL1/Gα15
A
 Peptide Opioid OPRM1 CHO-K1/OPRM1/Gα15
A
 Peptide Orexin OX1 CHO-K1/OX1
A
 Peptide Orexin OX2 CHO-K1/OX2
A
 Peptide Oxytocin OT / OXTR CHO-K1/OXTR
A
 Peptide Peptide P518 GPR103 CHO-K1/GPR103/Gα15
A
 Non-peptide Platelet Activating Factor PAF / PTAFR CHO-K1/PTAFR
A
 Peptide Prolactin Releasing Peptide PRLHR CHO-K1/PRLHR
A
 Non-peptide Prostanoid DP1 / PTGDR CHO-K1/DP1/Gα15
A
 Non-peptide Prostanoid DP2 / GPR44 CHO-K1/DP2/Gα15
A
 Non-peptide Prostanoid FP / PTGFR 293/FP/Gα15
A
 Non-peptide Prostanoid EP1 / PTGER1 293/EP1
A
 Non-peptide Prostanoid EP2 / PTGER2 CHO-K1/EP2/Gα15
A
 Non-peptide Prostanoid EP4 / PTGER4 293/EP4
M00485
A
 Non-peptide Prostanoid IP1 / PTGIR CHO-K1/IP1/Gα15
A
 Non-peptide Prostanoid TP / TBXA2R 293/TP
A
 Peptide Proteinase-activated Receptor PAR2 / F2RL1 CHO-K1/PAR2/Gα15
A
 Peptide Proteinase-activated Receptor PAR4 / F2RL3 CHO-K1/PAR4
A
 Non-peptide Proton-sensor GPR68 CHO-K1/GPR68/Gα15
A
 Non-peptide Purinergic P2Y1 1321N1/P2Y1
A
 Non-peptide Purinergic P2Y2 1321N1/P2Y2
A
 Non-peptide Purinergic P2Y4 1321N1/P2Y4
A
 Non-peptide Purinergic P2Y6 1321N1/P2Y6
A
 Non-peptide Purinergic P2Y11 1321N1/P2Y11
A
 Non-peptide Purinergic P2Y12 1321N1/P2Y12/Gα15
A
 Non-peptide Serotonin 5-HT1A / HTR1A CHO-K1/5-HT1A/Gα15
A
 Non-peptide Serotonin 5-HT2A / HTR2A CHO-K1/5-HT2A
A
 Non-peptide Serotonin 5-HT2B / HTR2B CHO-K1/5-HT2B
A
 Non-peptide Serotonin 5-HT2C / HTR2C CHO-K1/5-HT2C
A
 Non-peptide Serotonin 5-HT2C / HTR2C HEK293/5-HT2C
A
 Non-peptide Serotonin 5-HT4 / HTR4 CHO-K1/5-HT4/Gα15
A
 Non-peptide Serotonin 5-HT7 / HTR7 293/5-HT7/CRE-Luc
A
 Peptide Somatostatin SST1 CHO-K1/SST1/Gqi5
A
 Peptide Somatostatin SST2 CHO-K1/SST2/Gα15
A
 Peptide Somatostatin SST3 CHO-K1/SST3/Gα15
A
 Peptide Somatostatin SST4 CHO-K1/SST4/Gα15
A
 Peptide Somatostatin SST5 CHO-K1/SST5/Gα15
A
 Peptide Tachykinin NK1 / TACR1 CHO-K1/NK1
A
 Peptide Tachykinin NK2 / TACR2 CHO-K1/NK2
A
 Peptide Tachykinin NK3 / TACR3 CHO-K1/NK3
A
 Peptide Thyrtropin-releasing Hormone TRH1 CHO-K1/TRH1
A
 Peptide Urotensin UT2 CHO-K1/UT2/Gα15
A
 Peptide Vasopressin V1A / AVPR1A CHO-K1/V1A
A
 Peptide Vasopressin V1B / AVPR1B CHO-K1/V1B
A
 Peptide Vasopressin V2 / AVPR2 CHO-K1/V2/Gα15
A
   Orphan GPR120 CHO-K1/GPR120/Gα15
A
   Orphan MRGD / MRGPRD CHO-K1/MRGPRD/Gα15
M00467
A
   Orphan MRGX2 / MRGPRX2 CHO-K1/MRGPRX2
A
   Orphan OXGR1 CHO-K1/OXGR1/Gα15
M00483
A
   Orphan P2Y5 RH7777/P2Y5
M00472
A
   Orphan SUCNR1 / GPR91 CHO-K1/SUCNR1/Gα15
M00471
B
 Peptide Calcitonin CALCR / CT CHO-K1/CT/Gα15
B
 Peptide Calcitonin AMY1 (RAMP1 + CALCR) CHO-K1/AMY1/CRE-Luc
M00350
B
 Peptide Calcitonin AMY1 (RAMP1 + CALCR) CHO-K1/AMY1/Gα15
B
 Peptide Calcitonin AMY2 (RAMP2 + CALCR) CHO-K1/AMY2/Gα15
M00478
B
 Peptide Calcitonin AMY3 (RAMP3 + CALCR) CHO-K1/AMY3/Gα15
B
 Peptide Calcitonin AM1 (RAMP2 + CALCRL) CHO-K1/AM1
M00450
B
 Peptide Calcitonin AM2 (RAMP3 + CALCRL) CHO-K1/AM2/Gα15
M00479
B
 Peptide Corticotropin Releasing Factor CRF1 CHO-K1/CRF1/Gα15
B
 Peptide Corticotropin Releasing Factor CRF2 CHO-K1/CRF2/Gα15
B
 Peptide Glucagon GCGR CHO-K1/GCGR/Gα15
B
 Peptide Glucagon GCGR HEK293/GCGR/Gα15
B
 Peptide Glucagon GHRH 293/GHRH/Gα15
B
 Peptide Glucagon GIP CHO-K1/GIP/Gα15
B
 Peptide Glucagon GLP1 CHO-K1/GLP1/Gα15
B
 Peptide Glucagon GLP2 CHO-K1/GLP2/Gα15
B
 Peptide Glucagon SCTR CHO-K1/SCTR/Gα15
B
 Peptide Parathyroid Hormone PTH1 CHO-K1/PTH1/Gα15
B
 Peptide Parathyroid Hormone PTH2 293/PTH2/CRE-Luc
B
 Peptide VIP / PACAP PAC1 CHO-K1/PAC1/Gα15
B
 Peptide VIP / PACAP VPAC1 CHO-K1/VPAC1/Gα15
B
 Peptide VIP / PACAP VPAC2 CHO-K1/VPAC2/Gα15
C
 Non-peptide Calcium-sensor CASR CHO-K1/CASR
C
 Non-peptide Glutamate mGlu2 / GRM2 CHO-K1/GRM2/Gα15
    Control   CHO-K1/CRE-Luc
    Control   293/CRE-Luc
    Control   CHO-K1/Gα15
    Control   CHO-K1/Gqi5

All the GPCRs are available as Ready-to-UseTM frozen cells.
A part of the GPCRs are available as Membrane Preparations.

Ion Channel Stable Cell Lines

Name
Type
Channel
Accession Number
CHO-K1/hERG Potassium, voltage-gated hERG (Kv11.1)
NM_000238.2
HEK293/hERG Potassium, voltage-gated hERG (Kv11.1)
NM_000238.2
HEK293/hKv1.5 Potassium, voltage-gated hKv1.5
NM_002234
HEK293/hKv4.2 Potassium, voltage-gated hKv4.2
NM_012281
HEK293/hNav1.5 Sodium, voltage-gated hNav1.5
NM_000335
HEK293/hNav1.7 Sodium, voltage-gated hNav1.7
NM_002977

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