Cardiac Ion Channel Panel Profiling
Human ether-a-gogo-related (hERG) ion channel has a major role during the repolarization of the cardiac action potential, and it is well established that blockade of this ion channel can lead to potentially lethal arrhythmias. Several drugs had to be withdrawn from the market due to their hERG cardiac toxicities. As a result, hERG (IKr) pre-clinical safety data is an essential part of any investigational new drug submission recommended in FDA ICH S7B. Recently, investigations suggest that non-hERG cardiac ion channels are also involved in cardiac toxicity. GenScript offers cardiac ion channel panel for your safety risk assessment of drug candidates.
For all the listed cardiac ion channels, GenScript has developed manual patch clamp assays. For the most important ion channel, hERG, GenScript also offers higher throughput solutions to detect the hERG blockers in early drug discovery.
Cardiac Ion Channel Panel
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