endotoxin removal

Endotoxin Removal System

Endotoxin, also known as Lipopolysaccharide (LPS), is a cell membrane component of Gram-negative bacteria. A single E. coli cell contains about 2 million LPS molecules, which are released into the lysate during cell lysis. Endotoxins can initiate a strong immune response in mammalian hosts, resulting in systemic inflammatory response syndrome (SIRS) and/or sepsis. Endotoxins are often difficult to remove from solution due to the high variability of their molecular weights. In addition, endotoxins are relatively stable and insensitive to changes in temperature and pH.

Ligands with affinity to endotoxins can be coupled to an anion exchange system to increase the endotoxin binding strength. ToxinEraser™ Endotoxin Removal System is based on an affinity matrix of modified polymyxin B (PMB), which allows for efficient endotoxin removal from samples such as proteins, peptides, and antibodies. The final endotoxin level can be decreased to as low as 0.1 EU/ml * with repeated use of ToxinEraser™ Endotoxin Removal Resin.

*Final removal efficiency may vary depending on the sample type/source.

Key Features

  • High binding capacity at least 2, 000, 000 EU / ml (CV)
  • High Recovery Yield: >90% with minimized sample loss
  • High stability and high removal efficiency

endotoxin removal

Ordering Information

Cat. No.
Product Name
Size
Price
Quantity
L00338 ToxinEraserTM Endotoxin Removal Kit
1 kit
$110.00

Related Products

Cat. No.
Product Name
Size
Price
Quantity
L00402 ToxinEraserTM Endotoxin Removal Resin
1 ml
$60.00
L00350 ToxinSensorTM Chromogenic LAL Endotoxin Assay Kit
1 Kit (32 rxns)
$150.00
L00351 ToxinSensorTM Gel Clot Endotoxin Assay Kit
1 Kit
$90.00
M01063 ToxinSensorTM Endotoxin-free Pipette Tips (1 ml, Blue)
1 PK of 6 tips
$6.00
M01053 ToxinEraserTM Regeneration Buffer
125 ml
$25.00
M01054 ToxinEraserTM Equilibration Buffer
125 ml
$25.00