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GPCR Assay Services

GPCR, G protein-coupled receptor, is the largest known category of molecular targets with verified therapeutic value. It is comprised of approximately 600–1000 members. Currently, a great percentage of pharmaceutical drugs targets GPCRs for treatment of many diseases such as pain, asthma, hypertension, as well as immunological and neurological disorders.

To meet the demands of GPCR screening and profiling, GenScript not only provides a comprehensive collection of GPCR and parental cell lines, but also is able to construct any GPCR cell line through customization. Coupled with our advanced instrumentation and versatile assay platforms, GenScript brings a total solution for your biochemical and cell-based GPCR assays and speed up your drug discovery.

To expedite your drug discovery process, GenScript offers a variety of stable cell line products in our catalog, and a comprehensive collection of custom reagent services for gene, protein, peptide, and antibody.


Cat. No. Service
Price (USD)
SC1402
Custom GPCR Assay Services
Quotation

Assay Setup Showcases:

 
Fig1. Shown above are intracellular calcium responses from CHO-K1 cells stably expressing human NK3 Neurokinin receptors and from untransfected control cells. Cells were loaded with Calcium-4 and then stimulated with the indicated concentrations of Neurokinin B. Calcium responses were recorded on a FlexStation plate reader. Data represent the average +/- standard deviation of triplicate determinations.   Fig2. Shown above are the intracellular calcium responses of CHO-K1 cells stably expressing human arginine vasopressin receptor 1B and of untransfected control cells. Cells were loaded with Calcium-4 and then stimulated with the indicated concentrations of arginine vasopressin (AVP). Calcium responses were recorded on a FlexStation plate reader. Data represent the average +/- standard deviation of triplicate determinations.

Catalog GPCR Assay:

GenScript is continuously developing more GPCR catalog assays, utilizing various readouts such as Ca2+ flux, FRET, and luminescence, to cater the different needs of our customers. We constantly update our catalog assay list. However, for instances that your specific target(s) or readouts cannot be found within the list below, please feel free to contact our customer representatives and we'll provide a customized solution to your research.

Class
Ligand Type
GPCR Family
Receptor
Functional Assay
A
 Non-peptide Acetylcholine (muscarinic) M1 / CHRM1
A
 Non-peptide Acetylcholine (muscarinic) M2 / CHRM2
A
 Non-peptide Acetylcholine (muscarinic) M3 / CHRM3
A
 Non-peptide Acetylcholine (muscarinic) M4 / CHRM4
A
 Non-peptide Acetylcholine (muscarinic) M5 / CHRM5
A
 Non-peptide Adenosine ADORA1
A
 Non-peptide Adenosine ADORA2A
A
 Non-peptide Adenosine ADORA2B
A
 Non-peptide Adrenoceptors ADRA1A
A
 Non-peptide Adrenoceptors ADRA1B
A
 Non-peptide Adrenoceptors ADRA1D
A
 Non-peptide Adrenoceptors ADRA2A
A
 Non-peptide Adrenoceptors ADRA2C
A
 Non-peptide Adrenoceptors ADRB1
A
 Non-peptide Adrenoceptors ADRB2
A
 Non-peptide Adrenoceptors ADRB3
A
 Peptide Anaphylotoxin C5a / C5AR1
A
 Peptide Angiotensin AT2
Ca2+
A
 Peptide Apelin AGTRL1
A
 Non-peptide Bile acid GPBAR1
A
 Peptide Bombesin BB1
A
 Peptide Bombesin BB2
A
 Peptide Bombesin BB3
A
 Peptide Bradykinin B2
B
 Peptide Calcitonin CALCR
A
 Non-peptide Cannabinoid CNR1 / CB1
A
 Peptide Chemoattractant CMKLR1
A
 Peptide Cholecystokinin CCKA
A
 Peptide Cholecystokinin CCKB
B
 Peptide Corticotropin Releasing Factor CRF1
B
 Peptide Corticotropin Releasing Factor CRF2
A
 Non-peptide Dopamine D1 / DRD1
Ca2+, Luciferase, cAMP
A
 Non-peptide Dopamine D2 / DRD2
A
 Non-peptide Dopamine D2S / DRD2S
A
 Non-peptide Dopamine D5 / DRD5
A
 Peptide Endothelin EDNRA
A
 Peptide Endothelin EDNRB
A
 Non-peptide Free Fatty Acid GPR120
Ca2+
A
 Non-peptide Free Fatty Acid FFA1 / GPR40
A
 Non-peptide Free Fatty Acid FFA2 / GPR43
Ca2+
A
 Peptide Galanin GAL1
A
 Peptide Galanin GAL2
A
 Peptide Ghrelin GHSR
B
 Peptide Glucagon GCGR
Ca2+
B
 Peptide Glucagon GHRH
B
 Peptide Glucagon GLP2
B
 Peptide Glucagon SCTR
C
 Non-peptide Glutamate mGlu2 / GRM2
Ca2+
A
 Peptide Gonadotropin-releasing Hormone GNRHR
Ca2+
A
 Non-peptide Histamine H1
A
 Non-peptide Histamine H2
A
 Non-peptide Histamine H3
A
 Non-peptide Histamine H4
A
 Peptide KiSS1-derived Peptide KiSS1 / GPR54
A
 Non-peptide Leukotriene LTB4
Ca2+
A
 Non-peptide Mas-related gene MRGX2 / MRGPRX2
Ca2+
A
 Peptide Melanin-concentrating Hormone MCH1
A
 Peptide Melanin-concentrating Hormone MCH2
A
 Peptide Melanocortin MC2
A
 Peptide Melanocortin MC3
Ca2+, Luciferase
A
 Peptide Melanocortin MC4
A
 Peptide Melanocortin MC5
A
 Peptide Melatonin MT1
Ca2+
A
 Peptide Melatonin MT2
A
 Peptide Motilin MTLR
Ca2+
A
 Peptide Neuromedin U NMU1
A
 Peptide Neuropeptide FF NPFF1 / GPR147
Ca2+
A
 Peptide Neuropeptide S NPS1a
A
 Peptide Neuropeptide S NPS1b
Ca2+
A
 Peptide Neuropeptide Y NPY1
Ca2+
A
 Peptide Neuropeptide Y NPY4 / PPYR1
Ca2+
A
 Peptide Neurotensin NTS1
A
 Non-peptide Nicotinic Acid GPR109A
Ca2+
A
 Peptide N-Formyl Peptide FPR1
Ca2+
A
 Peptide N-Formyl Peptide FPRL1
A
 Peptide Opioid OPRD1
A
 Peptide Opioid OPRK1
A
 Peptide Opioid OPRM1
A
 Peptide Orexin OX1
Ca2+
A
 Peptide Orexin OX2
A
 Peptide Oxytocin OT / OXTR
B
 Peptide Parathyroid Hormone PTH1
Ca2+
B
 Peptide Parathyroid Hormone PTH2
β-Lac, Luciferase
A
 Peptide Peptide P518 GPR103
A
 Non-peptide Platelet Activating Factor PAF / PTAFR
A
 Peptide Prolactin Releasing Peptide PRLHR
A
 Non-peptide Prostanoid DP2 / GPR44
Ca2+
A
 Non-peptide Prostanoid FP / PTGFR
A
 Non-peptide Prostanoid EP1 / PTGER1
A
 Non-peptide Prostanoid EP2 / PTGER2
A
 Non-peptide Prostanoid IP1 / PTGIR
A
 Non-peptide Prostanoid TP / TBXA2R
A
 Peptide Proteinase-activated Receptor PAR2 / F2RL1
Ca2+
A
 Peptide Proteinase-activated Receptor PAR4 / F2RL3
A
 Non-peptide Proton-sensor GPR68
Ca2+
A
 Non-peptide Purinergic P2Y1
Ca2+
A
 Non-peptide Purinergic P2Y2
A
 Non-peptide Purinergic P2Y4
A
 Non-peptide Purinergic P2Y6
A
 Non-peptide Purinergic P2Y9
Ca2+
A
 Non-peptide Purinergic P2Y11
A
 Non-peptide Purinergic P2Y12
A
 Non-peptide Serotonin 5-HT1A / HTR1A
A
 Non-peptide Serotonin 5-HT2A / HTR2A
A
 Non-peptide Serotonin 5-HT2B / HTR2B
A
 Non-peptide Serotonin 5-HT2C / HTR2C
A
 Non-peptide Serotonin 5-HT4 / HTR4
Ca2+
A
 Non-peptide Serotonin 5-HT7 / HTR7
Luciferase
A
 Peptide Somatostatin SST2
A
 Peptide Somatostatin SST3
A
 Peptide Somatostatin SST4
A
 Peptide Somatostatin SST5
A
 Peptide Tachykinin NK1 / TACR1
A
 Peptide Tachykinin NK2 / TACR2
A
 Peptide Tachykinin NK3 / TACR3
A
 Peptide Thyrtropin-releasing Hormone TRH1
A
 Peptide Urotensin UT2
A
 Peptide Vasopressin V1A / AVPR1A
A
 Peptide Vasopressin V1B / AVPR1B
A
 Peptide Vasopressin V2 / AVPR2
B
 Peptide VIP / PACAP PAC1
B
 Peptide VIP / PACAP VPAC1
B
 Peptide VIP / PACAP VPAC2

Quotations and Ordering:

To request a quotation, please download and complete the and send it back by email or fax.

To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System.

Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.

Email: bioassay@genscript.com
Phone: 1-877-436-7274 (Toll-Free), 1-732-885-9188
Fax: 1-732-210-0262, 1-732-885-5878