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Ion Channel Target Solutions

Ion channels are multi-transmembrane proteins that help establish and control the small voltage gradient cross the plasma membrane of all living cells by allowing the flow of ions down their electrochemical gradient. Furthermore, many ion channels have been well recognized as important therapeutic targets for treating a number of diseases.

Manual patch clamp, referred to as the 'gold standard', is a traditional tool for direct ion current measurements. However, the extremely low throughput of manual patch clamp precludes the possibility of screening for a large number of compounds. Though new automated patch clamp instruments have increased the throughput greatly, the throughput of patch clamp technology is still the bottleneck of high throughput screening (HTS). Consequently, ion channel class is still underexploited as therapeutic targets. Recently patch clamp technology is mainly used for cardiotoxicity assessment against human ether-a-gogo-related (hERG) ion channel.

To implement ion channel HTS, GenScript has established fluorescence-based and radioisotope-based screening platforms. Integrating multiple platforms, GenScript can offer flexible solutions for your ion channel drug discovery covering assay development, primary screening, secondary screening, and selectivity/safety profiling.

Featured Services:

Screening Platforms:

Platform
Instrument
Throughput
Comment
 
Low
Electrophysiologic assay; gold standard.
QPatch 16
Medium
Electrophysiologic assay
FLIPRTetra®, FlexStation® 3, EnVison®, PHERAstar Plus
High
Cell-based functional assay
TopCount®
High
Membrane-based binding assay

Ready Ion Channel Assays:

Family
Receptor/Channel
Manual
QPatch 16
Functional
Binding
Voltage-gated potassium channels
hERG (hKv11.1)
Yes
Yes
Yes
Yes
Voltage-gated potassium channels
hKv1.5
Yes
Voltage-gated potassium channels
hKv4.2
Yes
Voltage-gated sodium channels
hNav1.5
Yes
Yes
Voltage-gated sodium channels
hNav1.7
Yes
P2X receptors
hP2X1
Yes
P2X receptors
hP2X3
Yes
Transient receptor potential channels
hTRPV1
Yes
Ionotropic glutamate receptors
hGluK2
Yes
Glycine receptors
hGlyR α1/β
Yes

Quotations and Ordering

To request a quotation, please download and complete the quotation form and send it back by email or fax.

  • For manual patch clamp platform, please download the Quotation;

  • For automated patch clamp platform, please download the Quotation;

  • For functional cell-based platform, please download the Quotation;

  • For radioisotope-based platform, please download the Quotation;

To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System.

Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.