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Kinase Target Solutions

Kinases play many important roles in cellular signaling pathways and various other complex processes involving phosphorylation. The dysregulation of kinases is often associated with pathogenic pathways of many diseases, such as cancer, inflammatory diseases, neural disorders, and many metabolic disorders. Protein kinases have extraordinary potential as drug targets.

To address the demand of kinase drug discovery, GenScript has developed both biochemical and cell-based kinase assay platforms. All of the biochemical kinase assays in the kinase panel are available for high throughput screening and profiling. In addition to services, GenScript offers kinase assay reagents for your in-house projects.

Featured Services:

Kinase assay development for high throughput screening
Kinase expression, purification, and activity assay
Kinase substrate determination based on peptide library
High throughput screening and profiling

Screening Platforms:

Platform	Instrument	Assay	Comment
Biochemical	EnVison^®, PHERAstar Plus	HTRF^® Transcreener^® ADP	Full-length kinase, activity-based assay, suitable for primary screening.
Cell-based	Odyssey^®	In-Cell Western^TM	Whole cell enviroment, suitable for secondary screening.

Assay Setup Showcases:


Name: EGFR T790M Source: Human Substrate: Abl1 peptide substrate (EAIYAAPFAKKK) Reference Compound: Staurosprine Measured Product: ADP Detection Technique: HTRF		Name: PKA Source: Human Substrate: Kemptide peptide substrate (LRRASLG) Reference Compound: H-89 Measured Product: ADP Detection Technique: HTRF

Kinase Panel:

GenScript offers high throughput screening and profiling services against the kinase panel. If you can’t find kinase of interest in the panel, please feel free to contact us for support.

Part of kinases are available as catalog kinase products for order. See kinase assay reagents.

Serine/Threonine Kinases

AGC

Family	Name
AKT	AKT1
	AKT2
	AKT3
DMPK	ROCK2
PKA	PKA Cα
PKC	PKCα
	PKCβ2
	PKCθ
	PKCζ
P70	p70S6
PDK1	PDK1
RSK	RSK2

CaMK

Family	Name
CaMKL	AMPK(α1/β1/γ1)
	AMPK(α1/β1/γ2)
	AMPK(α1/β1/γ3)
	AMPK(α1/β2/γ1)
	AMPK(α1/β2/γ2)
	AMPK(α2/β1/γ1)
	AMPK(α2/β1/γ2)
	AMPK(α2/β1/γ3)
	AMPK(α2/β2/γ1)
	AMPK(α2/β2/γ3)
DAPK	DAPK1
DAPK	DAPK2
PIM	PIM1
MAPKAPK	MAPKAPK3
MELK	MELK
MLCK	MYLK2
RAD53	CHK2

CK1

Family	Name
CK1	CK1δ

CMGC

Family	Name
CDK	CDK2/Cyclin E
	CDK3/Cyclin E
	CDK4/Cyclin D1
	CDK4/Cyclin D3
GSK	GSK3α
GSK	GSK3β
MAPK	ERK1
MAPK	ERK2
SPRK	SRPK1

TKL

Family	Name
B-RAF	B-RAF
B-RAF	B-RAF V600E
RAF1	RAF1
RAF1	RAF1 Y340D/Y341D
IRAK	IRAK4
TGFβ	ACVR1
TGFβ	ACVR1B

STE

Family	Name
MAP4K/STE20	HGK
	PAK1
	PAK2
	PAK3
	MINK1
	MST1
MEK	MEK1/MAPKK1
MEK	MEK6/MAPKK6

Others

Family	Name
Aurora	Aurora-A
IKK	TBK1
NEK	NEK7
PLK	PLK1
	PLK2
	PLK3

Tyrosine Kinases

RTK

Family	Name
AXL	MER
AXL	TYRO3/SKY
Eph Kinase	EPHA2
	EPHA3
	EPHA5
EGFR	EGFR
	EGFR T790M
	HER4/ERBB4
FGFR	FGFR1
	FGFR2
	FGFR3
	FGFR4
InsR	INSR
InsR	IGF-1R
MET	MET
MET	MET M1250T
PDGFR	KIT
PDGFR	FLT3
RET	RET
SEV	ROS1
TIE	TIE2/TEK
TRK	TRK-B
VEGFR	VEGFR1
VEGFR	VEGFR2

CTK

Family	Name
CSK	CSK
SRC	BLK
	FYN
	LYN A
	LCK
	SRC
SYK	ZAP-70
FER	FER

Quotations and Ordering:

To request a quotation, please download and complete the and send it back by email or fax.

To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System.

Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.

	Email: bioassay@genscript.com
	Phone: 1-877-436-7274 (Toll-Free), 1-732-885-9188
	Fax: 1-732-210-0262, 1-732-885-5878