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Kinase Assay Service

Kinase Target Solutions

Kinases play many important roles in cellular signaling pathways and various other complex processes involving phosphorylation. The dysregulation of kinases is often associated with pathogenic pathways of many diseases, such as cancer, inflammatory diseases, neural disorders, and many metabolic disorders. Protein kinases have extraordinary potential as drug targets.

To address the demand of kinase drug discovery, GenScript has developed both biochemical and cell-based kinase assay platforms. All of the biochemical kinase assays in the kinase panel are available for high throughput screening and profiling. In addition to services, GenScript offers kinase assay reagents for your in-house projects.

Featured Services:

Screening Platforms:

Platform
Instrument
Assay
Comment
Biochemical
EnVison®, PHERAstar Plus
HTRF® Transcreener® ADP
Full-length kinase, activity-based assay, suitable for primary screening.
Odyssey®
In-Cell Western™
Whole cell enviroment, suitable for secondary screening.

Assay Setup Showcases:

EGFR assay
PKA assay
Name: EGFR T790M
Source: Human
Substrate: Abl1 peptide substrate (EAIYAAPFAKKK)
Reference Compound: Staurosprine
Measured Product: ADP
Detection Technique: HTRF
Name: PKA
Source: Human
Substrate: Kemptide peptide substrate (LRRASLG)
Reference Compound: H-89
Measured Product: ADP
Detection Technique: HTRF

Kinase Panel:

GenScript offers high throughput screening and profiling services against the kinase panel. If you can't find kinase of interest in the panel, please feel free to contact us for support.

Part of kinases are available as catalog kinase products for order. See kinase assay reagents.

Serine/Threonine Kinases

AGC
Family
Name
AKT AKT1
AKT2
AKT3
DMPK ROCK2
PKA PKA Cα
PKC PKCα
PKCβ2
PKCθ
PKCζ
P70 p70S6
PDK1 PDK1
RSK RSK2

CaMK
Family
Name
CaMKL AMPK(α1/β1/γ1)
AMPK(α1/β1/γ2)
AMPK(α1/β1/γ3)
AMPK(α1/β2/γ1)
AMPK(α1/β2/γ2)
AMPK(α2/β1/γ1)
AMPK(α2/β1/γ2)
AMPK(α2/β1/γ3)
AMPK(α2/β2/γ1)
AMPK(α2/β2/γ3)
DAPK DAPK1
DAPK2
PIM PIM1
MAPKAPK MAPKAPK3
MELK MELK
MLCK MYLK2
RAD53 CHK2

CK1
Family
Name
CK1 CK1δ

CMGC
Family
Name
CDK CDK2/Cyclin E
CDK3/Cyclin E
CDK4/Cyclin D1
CDK4/Cyclin D3
GSK GSK3α
GSK3β
MAPK ERK1
ERK2
SPRK SRPK1

TKL
Family
Name
B-RAF B-RAF
B-RAF V600E
RAF1 RAF1
RAF1 Y340D/Y341D
IRAK IRAK4
TGFβ ACVR1
ACVR1B

STE
Family
Name
MAP4K/STE20 HGK
PAK1
PAK2
PAK3
MINK1
MST1
MEK MEK1/MAPKK1
MEK6/MAPKK6

Others
Family
Name
Aurora Aurora-A
IKK TBK1
NEK NEK7
PLK PLK1
PLK2
PLK3


Tyrosine Kinases

RTK
Family
Name
AXL MER
TYRO3/SKY
Eph Kinase EPHA2
EPHA3
EPHA5
EGFR EGFR
EGFR T790M
HER4/ERBB4
FGFR FGFR1
FGFR2
FGFR3
FGFR4
InsR INSR
IGF-1R
MET MET
MET M1250T
PDGFR KIT
FLT3
RET RET
SEV ROS1
TIE TIE2/TEK
TRK TRK-B
VEGFR VEGFR1
VEGFR2

CTK
Family
Name
CSK CSK
SRC BLK
FYN
LYN A
LCK
SRC
SYK ZAP-70
FER FER

Quotations and Ordering:

To request a quotation, please download and complete the Kinase Assay Service and send it back by email or fax.

To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System.

Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.