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*For Non-Clinical Research Use Only*
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Substance P, Free Acid  |
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| Full Name |
Substance P, Free Acid |
| Alias |
SPOH |
|
Sequence
(one-letter code) |
RPKPQQFFGLM |
Sequence
(three-letter code) |
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET} |
| Description |
The conformation of substance P (free acid) (SPOH) has been investigated in dimethylsulfoxide (DMSO), water and dipalmitoylphosphotidylcholine (DPPC) bilayers by two-dimensional NMR and restraint molecular dynamics simulations. The observed NOE patterns for substance P (free acid) in these media are very much different from each other. The conformation of substance P (free acid) in DPPC bilayers is characterized by gamma-bends at Pro4,Gln6and Phe7, which are stabilized by hydrogen bonding between Lys3CO-->Gln5NH, Gln5CO-->Phe7NH and Gln6CO-->Phe8NH, respectively. The absence of biological activity in SPOH has been attributed to the absence of any helix like structure at the central residues and absence of any interresidue interaction with C-terminal OH group, in DPPC bilayers, a feature shown to be an important prerequisite for SP and SP agonists to bind to the NKI tachykinin receptor. |
| Purity |
> 95% |
| Storage |
Store at -20°C. |
| Notes |
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Document-HPLC: 1968_20060721145614.PDF (PDF)