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*For Non-Clinical Research Use Only*
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[Tyr 8]-Substance P  |
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|
| Full Name |
[Tyr8]-Substance P |
| Alias |
Y8SP; [Tyr8]SP |
|
Sequence
(one-letter code) |
RPKPQQFYGLM-NH2 |
Sequence
(three-letter code) |
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{TYR}{GLY}{LEU}{MET}-NH2 |
| C-Terminal |
NH2 |
| Description |
The conformation of [Tyr8]Subtance P (Y8SP) in dimethylsulfoxide (DMSO), water, and dipalmitoyl phosphatidylcholine (DPPC) bilayers has been investigated by two-dimensional nmr and molecular dynamics simulations. Molecular modeling of the conformation of [Tyr8]Subtance P by incorporating nuclear Overhauser effects as distance restraints shows wide differences in its conformation in the three media. The random coil structure seen in water is transformed into a -turn around the segment Gln5-Gln6-Phe7-Tyr8 when Y8SP is incorporated into DPPC bilayers. The lower biological activity of Y8SP compared to the native peptide (SP) has been attributed to the absence of any helix like structure at the central residues. |
| Solubility |
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Purity |
> 95% |
| Storage |
Store at -20°C. Keep tightly closed. |
| Notes |
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Related Products
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1 |
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-HPLC: 1971_20060721145614.PDF (PDF)