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Sarafotoxin 6c

Full Name Sarafotoxin 6c
Alias
SRTX-c
Documents
Document-MSDS: 4720_20080703040024.PDF (PDF)
TECHNICAL MANUAL: 12464_20100407015038.PDF (PDF)
Figures
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Reference
Sequence
(one-letter code)
CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: 1-15 and 3-11)
Sequence
(three-letter code)
{CYS}{THR}{CYS}{ASN}{ASP}{MET}{THR}{ASP}{GLU}{GLU}{CYS}{LEU}{ASN}{PHE}{CYS}{HIS}{GLN}{ASP}{VAL}{ILE}{TRP}
Chemical Bridge
1-15 and 3-11
Description
S6c, as a selective ETB endothelin receptor agonist. its administration can cause a transient fall in mean arterial blood pressure (MABP) prior to occlusion and attenuated the fall in MABP induced by coronary occlusion.
Solubility
Insoluble in water. Peptide is very acidic.Rehydrate 100 mg of peptide with at least 1ml of pH8.0 buffer orrehydrate the content with 30 ml-100 ml DMSO - then dilute up the content with water to the desired concentration.
Purity
> 95%
Storage
Store at -20°C. Keep tightly closed. Store in a cool dry place.
Notes
Most acidic. Causes strong vasoconstriction of the coronary vessels as well as various changes in the ECG that lead to A-V block and cardiac arrest.
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