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Protease Assay Service

Protease Target Solutions

Approximately 500 putative proteases have been identified in human genome. Through controlling complex proteolytic activities, proteases participate in a wide range of physiological processes. Many of them have been utilized as targets for therapeutic intervention, such as Dipeptidyl Peptidase IV (DPP-IV) and HIV-1 protease for diabetes and AIDS, respectively. However, precise roles of many proteases remain unknown in many diseases.

To speed up the drug discovery process that involves protease targets, GenScript has developed a protease assay panel for protease screening and profiling. Moreover, custom assay development service is available to facilitate your drug screening against protease targets of your interest.

Featured Services

  • Assay development for high throughput screening
  • Protease substrate determination based on peptide library
  • High throughput screening and profiling

Assay Setup Showcases


MMP-1 Assay   Factor Xa Assay
Name: MMP1
Source: Human
Substrate: Mca-PLGL-Dpa-AR
Reference Compound: NNGH
Measured Product: Mca-peptides
Detection Technique: Fluorimetry
  Name: Factor Xa
Source: Human
Substrate: CH3OCO-D-CHA-Gly-Arg-pNA-AcOH
Reference Compound: PPACK
Measured Product: pNA
Detection Technique: Colorimetry

Protease Panel:

GenScript has assembled the largest protease panel in the industry which covers over 70 proteases. Our comprehensive protease panel profiling will boost your capability in evaluating structure-activity relationship (SAR) in drug development process and minimize the risks in overall clinical stage.

If you can't find protease of interest in ready catalog assays, please feel free to contact us for support.

Aspartate Proteases
Protease Family
Protease Name
Cathepsins Cathepsin D
Cathepsin E
HIV HIV-1
Pepsins Pepsin
Other Proteases Renin

Serine Proteases
Protease Family
Protease Name
Clotting Factors Thrombin
Tissue plasminogen activator
Factor Xa
DPP (Dipeptidyl Peptidases) DPP-4
DPP7
DPP8
DPP9
FAP
Cathepsins Cathepsin G
Kallikreins KLK-1
KLK-2
KLK-5
Tryptase Tryptase, βII
Tryptase ε/BSSP4
Complement Proteases Complement C1r Subcomponent
Complement C1s Subcomponent
Complement MASP3 Catalytic Domain
Other Proteases Airway trypsin-like protease/HAT
Marapsin/Pancreasin
Matriptase/ST14 Catalytic Domain
Neutrophil Elastase
Proteinase 3
Trypsin
u-Plasminogen activator/Urokinase

Complex Proteases
Protease Family
Protease Name
Proteasome 20S Proteasome
Cysteine Proteases
Protease Family
Protease Name
Caspases Caspase-1
Caspase-2
Caspase-3
Caspase-4
Caspase-5
Caspase-6
Caspase-7
Caspase-8
Caspase-9
Caspase-10
Cathepsins Cathepsin B
Cathepsin C
Cathepsin H
Cathepsin K
Cathepsin L
Cathepsin S
Cathepsin V
Cathepsin X/Z/P
Other Proteases Calpain
Legumain

Metalloproteases
Protease Family
Protease Name
ACE ACE
ACE2
ADAM Enzymes ADAM10
ADAM17
DPP (Dipeptidyl Peptidases) DPP3
Endothelin-Converting Enzymes ECE-1
ECE-2
MMPs (Matrix Metalloproteinases) MMP1
MMP2
MMP3
MMP7
MMP8
MMP9
MMP10
MMP12
MMP13
MMP14
MMP20
Neprilysins Neprilysin
Neprilysin 2
Other Proteases IDE (insulysin)

Quotations and Ordering

  • To request a quotation, please download and complete the Protease Assay Service and send it back by email or fax.
  • To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System.

Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.