Protease Target Solutions
Approximately 500 putative proteases have been identified in human genome. Through controlling complex proteolytic activities, proteases participate in a wide range of physiological processes. Many of them have been utilized as targets for therapeutic intervention, such as Dipeptidyl Peptidase IV (DPP-IV) and HIV-1 protease for diabetes and AIDS, respectively. However, precise roles of many proteases remain unknown in many diseases.
To speed up the drug discovery process that involves protease targets, GenScript has developed a protease assay panel for protease screening and profiling. Moreover, custom assay development service is available to facilitate your drug screening against protease targets of your interest.
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Featured Services:
- Assay development for high throughput screening
- Protease substrate determination based on peptide library
- High throughput screening and profiling
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Assay Setup Showcases:
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Name: MMP1
Source: Human
Substrate: Mca-PLGL-Dpa-AR
Reference Compound: NNGH
Measured Product: Mca-peptides
Detection Technique: Fluorimetry |
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Name: Factor Xa
Source: Human
Substrate: CH3OCO-D-CHA-Gly-Arg-pNA-AcOH
Reference Compound: PPACK
Measured Product: pNA
Detection Technique: Colorimetry |
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Protease Panel:
GenScript has assembled the largest protease panel in the industry which covers over 70 proteases. Our comprehensive protease panel profiling will boost your capability in evaluating structure-activity relationship (SAR) in drug development process and minimize the risks in overall clinical stage.
If you can’t find protease of interest in ready catalog assays, please feel free to contact us for support. |
Aspartate Proteases
Serine Proteases
Protease Family |
Protease Name |
| Clotting Factors |
Thrombin |
| Tissue plasminogen activator |
| Factor Xa |
| DPP (Dipeptidyl Peptidases) |
DPP-4 |
| DPP-7 |
| DPP-8 |
| DPP-9 |
| FAP |
| Cathepsins |
Cathepsin G |
| Kallikreins |
KLK-1 |
| KLK-2 |
| KLK-5 |
| Tryptase |
Tryptase, βII |
| Tryptase ε/BSSP4 |
| Complement Proteases |
Complement C1r Subcomponent |
| Complement C1s Subcomponent |
| Complement C2 |
| Complement MASP3 Catalytic Domain |
| Other Proteases |
Airway trypsin-like protease/HAT |
| Marapsin/Pancreasin |
| Matriptase/ST14 Catalytic Domain |
| Neutrophil Elastase |
| Prolyl oligopeptidase/PreP |
| Proteinase 3 |
| Trypsin |
| u-Plasminogen activator/Urokinase |
Complex Proteases
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Cysteine Proteases
Metalloproteases
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Quotations and Ordering:
 To request a quotation, please download and complete the  and send it back by email or fax.
To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System.
Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.
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Email: bioassay@genscript.com |
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Phone: 1-877-436-7274 (Toll-Free), 1-732-885-9188 |
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Fax: 1-732-210-0262, 1-732-885-5878 |
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