Catalog Products » Growth Factors » Human Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) (Receptor Grade)
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Manual
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Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) (Receptor Grade), human

*This product has been discontinued!*
Human Long Arg3 Insulin-like Growth Factor-I (Long R3 IGF-I) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Scientists have engineered this analog with the express purpose of increasing biological activity. Human Long-R3-IGF-I is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs. Recombinant human Long Arg3 Insulin-like Growth Factor-I (Long R3 IGF-I), produced in E. coli, is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9,111 Da.
Z02188
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Product Introduction
Purity The purity of GenScript Recombinant Human Long-R3-IGF-I is greater than 95% as determined by the following methods:
(a) RP-HPLC analysis
(b) Reducing and non-reducing SDS-PAGE silver-stained gel analysis
Endotoxin Level The endotoxin level of GenScript Recombinant Human Long-R3-IGF-I is below 0.1 ng/μg (1 IEU/μg) of Long-R3-IGF-I.
Formulation The protein was lyophilized after extensive dialysis against 300mM NaAc buffer.
Reconstitution It is recommended that the lyophilized GenScript Long-R3-IGF-I be reconstituted in 500 mM acetic acid not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
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Background
Target Background This product has been replaced by Z03177

Human Long Arg3 Insulin-like Growth Factor-I (Long R3 IGF-I) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Scientists have engineered this analog with the express purpose of increasing biological activity. Human Long-R3-IGF-I is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.
Recombinant human Long Arg3 Insulin-like Growth Factor-I (Long R3 IGF-I), produced in E. coli, is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9,111 Da.
Synonyms Human Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) (Receptor Grade)
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