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Endostatin, Human



Cat. No.
Name
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Selected
Z02533-100
100 μg
$95
Z02533-20
20 μg
$39

Protein Endostatin, Human
Abbreviated Name-1
Endostatin;
Documents
Endostatin, HumanDocument-MSDS: 12635_20100419060138.PDF (PDF)
Purity
Greater than 97% by SDS-PAGE
Endotoxin Level
Endotoxin level is less than 0.1 ng per μg (1EU/μg) of Endostatin.
Biological Activity
Determined by Endothelial Cell Tube Formation. The cells treated with 10μg/ml Endostatin showed significant anti-angiogenesis effect.
Source
P. Pichia
Description
Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Synonyms
Endostatin;
Formulation
The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Storage
The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.
Document-COA
  • 12637_20100419060450.PDF
  • 12636_20100419060427.DOC
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