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Endostatin, Human


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Z02533-20 Endostatin, Human
20 μg
$39.00
Z02533-100 Endostatin, Human
100 μg
$95.00



Synonyms Endostatin;
Description Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Amino Acid Sequence
AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA
VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL
FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV
WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG
QSAASCHHAY IVLCIENSFM TASK
Source P. pastoris
Species Human
Biological Activity Determined by Endothelial Cell Tube Formation. The cells treated with 10μg/ml Endostatin showed significant anti-angiogenesis effect.

Formulation The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Purity Greater than 97% by SDS-PAGE
Endotoxin Level Endotoxin level is less than 0.1 ng per μg (1EU/μg) of Endostatin.
Storage The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.

Endostatin, Human

Endostatin, Human

Endostatin, Human

Endostatin, Human




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