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Bone Morphogenetic Protein-4 (BMP-4), Human



Cat. No.
Name
Size   
Price
Selected
Z02750-1
1 mg
$2,700
Z02750-10
10 μg
$159

Full Name Bone Morphogenetic Protein-4 (BMP-4), Human
Abbreviated Name-1
Bone Morphogenetic Protein-4 (BMP-4), Human;
Documents
Bone Morphogenetic Protein-4 (BMP-4), HumanDocument-MSDS: Z02750_MSDS.pdf (pdf)
Description
Human BMP-4 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor ß (TGF-ß) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they havesince been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP-4 is synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Source
Escherichia coli.
Molecular Weight
Approximately 13.0 kDa, a monomeric, non-glycosylated polypeptide chain containing 116 amino acids.
Purity
>95% by SDS-PAGE and HPLC analyses.
Endotoxin Level
Less than 0.2EU/ug of rHuBMP-4 as determined by LAL method.
Storage
This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
Formulation
Lyophilized from a 0.2µm filtered concentrated solution in 20mM Na2CO3 buffer, pH 9.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Usage
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Applications
1. Molecular standard (Western, ELISA) in studying secreted BMP-4;
2. Preparing antibodies for BMP-4 monomer;
3. Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE.
Document-COA
  • Z02750_R52031204.pdf
  • Z02750_R50581204.pdf
  • C51181406_Z02750_COA.pdf
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