TFF3, Human

The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.

Price	$180.00
Cat. No.	Z02904-20
Size	20 μg 1 mg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Human

Protein Construction

TFF3 (Glu22-Phe80)
Accession # Q07654

Purity

> 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC

Endotoxin Level

< 1 EU/μg of protein by LAL method

Biological Activity

Fully biologically active when compared to standard. The ED₅₀ as determined by a chemotaxis bioassay using human MCF-7 cells is less than 10.0 μg/ml, corresponding to a specific activity of > 100.0 IU/mg.

Expression System

E. coli

Theoretical Molecular Weight

6.6 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml.

Storage & Stability

Upon receiving, this product remains stable for 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. Avoid repeated freeze-thaw cycles.

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Background

Target Background

Synonyms

Trefoil Factor 3; TFF-3; ITF; P1B; TFI

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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.