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Interleukin-19 (IL-19), Human



Cat. No.
Name
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Z02932-2
2 μg
$65

Protein Interleukin-19 (IL-19), Human
Synonyms
Melanoma differentiation association like protein
Documents
IL-19, HumanDocument-MSDS: Z02932_MSDS.pdf (pdf)
Species
Human
Purity
> 95 % by SDS-PAGE and HPLC analyses.
Endotoxin Level
Less than 1 EU/μg of rHuIL-19 as determined by LAL method.
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human IL-20Rα and human IL-20Rβ co-transfected murine BaF3 pro-B cells is less than 1.5 ng/ml, corresponding to a specific activity of > 6.7 × 105 IU/mg.
Source
E. coli
Amino Acid Sequence
LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE
TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM
QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL
AWINKNHEVM SSA
Molecular Weight
Approximately 17.9 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.
Description
Human Interleukin 19 (IL-19) is a member of the IL-10 family of related cytokines. IL-19 expression has been observed in keratinocytes and monocytes. IL-19 binds a receptor complex consisting of IL-20R alpha and the IL-20 R beta. This receptor complex is also shared by IL-20 and IL-24.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Storage
This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Document-COA
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