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Interleukin-1 Beta (IL-1 Beta), Rat



Cat. No.
Name
Size   
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Z03014-1
1 mg
$2,100

Protein Interleukin-1 Beta (IL-1 Beta), Rat
Abbreviated Name-1
IL1F2, IL1B, Catabolin, Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Documents
Interleukin-1 Beta (IL-1 Beta), RatDocument-MSDS: Z03014_MSDS.pdf (pdf)
Purity
> 95% by SDS-PAGE and HPLC analyses.
Endotoxin Level
< 0.2 EU/μg, determined by LAL method.
Biological Activity
ED50 < 10 pg/ml, measured by a cell proliferation assay using mouse D10S cells, corresponding to a specific activity of > 1.0× 108 units/mg.
Source
E. coli
Amino Acid Sequence
Val117-Ser268 (accession number: Q63264).
Molecular Weight
17.3 kDa, observed by reducing SDS-PAGE.
Description
Interleukin-1 Beta (IL-1 Beta) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta bind to the same receptor and have similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.

Recombinant rat Interleukin-1 Beta (rat IL-1 Beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 152 amino acids. A fully biologically active molecule, recombinant rat IL-1 Beta protein has a molecular mass of 17.3kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Synonyms
IL1F2, IL1B, Catabolin, Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Formulation
Lyophilized after extensive dialysis against PBS.
Reconstitution
Reconstituted in ddH2O at 100 μg/ml.
Storage
Lyophilized recombinant rat Interleukin-1 Beta (IL-1 Beta) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, recombinant rat IL-1 Beta should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Document-COA
  • P50011302_Z03014_COA.pdf
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