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Interleukin-1 beta (IL-1β), Rat


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Product Name
Size
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Z03014-50 IL-1β, Rat
50 μg
$275.00
Z03014-10 IL-1β, Rat
10 μg
$85.00
Z03014-1 IL-1β, Rat
1 mg
$2100.00



Synonyms IL1F2, IL1B, Catabolin, Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Description Interleukin-1 Beta (IL-1 Beta) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta bind to the same receptor and have similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.

Recombinant rat Interleukin-1 Beta (rat IL-1 Beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 152 amino acids. A fully biologically active molecule, recombinant rat IL-1 Beta protein has a molecular mass of 17.3kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Amino Acid Sequence
VPIRQLHCRL RDEQQKCLVL SDPCELKALH LNGQNISQQV
VFSMSFVQGE TSNDKIPVAL GLKGLNLYLS CVMKDGTPTL
QLESVDPKQY PKKKMEKRFV FNKIEVKTKV EFESAQFPNW
YISTSQAEHR PVFLGNSNGR DIVDFTMEPV SS
Source E. coli
Accession No Q63264
Species Rat
Biological Activity ED50 < 10 pg/ml, measured by a cell proliferation assay using mouse D10S cells, corresponding to a specific activity of > 1.0× 108 units/mg.

Molecular Weight 17.3 kDa, observed by reducing SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Purity > 95% by SDS-PAGE and HPLC analyses.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant rat Interleukin-1 Beta (IL-1 Beta) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, recombinant rat IL-1 Beta should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

IL-1β, Rat

IL-1β, Rat

IL-1β, Rat




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