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Interleukin 13 (IL-13), Human

Cat. No.
1 mg

Full Name Interleukin 13 (IL-13), Human
Abbreviated Name-1
NC30 (Human), P600 (Murine);IL-13 (human)
Interleukin 13 (IL-13), HumanDocument-MSDS: Z03020_MSDS.pdf (pdf)
Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and mouse IL-13 is cross-species reactive.
Recombinant human interleukin 13 expressed in CHO cells is glycosylated protein with molecular weight range from 25 to 45 kDa shown in non-reducing SDS-PAGE.
Molecular Weight
25-45 kDa, observed by non-reducing SDS-PAGE.
> 95% as analyzed by SDS-PAGE.
Endotoxin Level
< 0.2 EU/μg, determined by LAL method.
Biological Activity
ED50 < 15 ng/ml, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 6.7×105 units/mg.
Lyophilized recombinant human Interleukin 13 (IL-13) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhIL-13 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Lyophilized after extensive dialysis against PBS.
Reconstituted in ddH2O or PBS at 100 μg/ml.
Amino Acid Sequence
S19-N132 (Accession # P35225).
For research use only
  • B60111304_Z03020_COA.pdf
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