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PDGF-BB, Porcine

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Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in an animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, and PDGF-AB. It is involved in many biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).
Z03778
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Product Introduction
Species Porcine
Protein Construction
PDGF-BB (Arg81-Ala185)
Accession # A0A287ADF0
Purity ≥ 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity ED50 < 20.0 ng/ml, measured by a cell proliferation assay using BALB/3T3 cells, corresponding to a specific activity of > 5.0 × 104 U/mg.
Expression System P. pastoris
Theoretical Molecular Weight 11.9 kDa
Apparent Molecular Weight 10-18 kDa, on SDS-PAGE under reducing conditions
Formulation Lyophilized from a 0.2 μm filtered solution in 20 mM NaAc, pH 5.0
Reconstitution Before opening, centrifuge the vial briefly to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O up to 100 μg/ml
Storage & Stability Upon receiving, this product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 1 week at 4℃ or for 3 months at -20℃ or below. Avoid repeated freeze-thaw cycles.
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PDGF-BB, Porcine

The ED50 as determined by a cell proliferation assay using BALB/3T3 cells is 4.160 ng/ml. »

PDGF-BB, Porcine

Lane 1: 2 µg of PDGF-BB, Porcinereducing (N)
Lane 2: 2 µg of PDGF-BB, Porcinereducing (R)
The purity is greater than 95% as analyzed by SDS-PAGE »

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Background
Target Background Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in an animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, and PDGF-AB. It is involved in many biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).
Synonyms PDGFBB; PDGF-BB
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.